Early rehabilitation in patients with hypercapnic respiratory failure.

• Conditions: Hypercapnic respiratory failure; Respiratory - Other respiratory disorders / diseases; Physical Medicine / Rehabilitation - Other physical medicine / rehabilitation

• Registration Number: ACTRN12605000215628
• Lead Sponsor: Royal Prince Alfred Hospital, Woolcock Institute of Medical Research, University of Sydney

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Results First Posted: 1900-01-01
• Study Start: 2005-08-25
• Last Update Posted: 13 January 2020

Recruitment & Eligibility

• Status: Stopped early
• Sex: All
• Target Recruitment: 60

Inclusion Criteria

Daytime PaCO2 greater than 45mmHg, pH greater than 7.34, 3 out of 4 of : increase in FiO2 required to maintain SpO2 greater than 90% compared to baseline, increase in dyspnoea in the past week, increase in cough/sputum past week, decrease in subjective exercise tolerance over past week.

Exclusion Criteria

pH equal to or less than 7.34, gross hypoxaemia, unstable angina or myocardial infarct in previous month, uncontrolled hypertension, febrile, resting tachycardia, orthopaedic or neurological conditions that limit exercise capacity, decreased level of conciousness, major psychiatric illness.

Study & Design

• Study Type: Interventional
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Exercise capacity - measured by the 6MWT and an unsupported arm endurance test[Comparisons made within group pre and post intervention, and between groups pre and post intervention, and in proportion of change from pre-post intervention];Dyspnoea - using Borg dysponea scale (0-10)[Comparisons made within group pre and post intervention, and between groups pre and post intervention, and in proportion of change from pre-post intervention]

Secondary Outcome Measures

Name	Time	Method
SpO2% - using pulse oximeter[Measured continuously throughout exercise];Rate of perceived exertion - using Borg RPE scale (0-10)[Measured each minute during exercise tests];Quality of life - using St Georges Respiratory Questionnaire (SGRQ) and the Maugeri Foundation Respiratory Failure Questionnaire (MRF-28)[Measured pre and post training and at three month review]