TCTR20211004007已完成4 期
Pulse Dose versus Continuous Dose of Calciferol on Vascular Stiffness in Diabetic Kidney Disease: A Randomized Trial
avamindradhiraj University0 个研究点目标入组 30 人开始时间: 2021年10月4日最近更新:
适应症
试验速览
- 阶段
- 4 期
- 状态
- 已完成
- 发起方
- 入组人数
- 30
研究概览
简要总结
10 weeks of calciferol given to CKD patients with T2DM and 25(OH)D less than 30 ng/mL could achieve a more reduction of Cardio-ankle vascular index in the pulse dose than in the continuous dose groups. Although no statistically significant change in Carotid-femoral pulse wave velocity (cfPWV), there seemed to be a bigger cfPWV reduction in the pulse dose, with the achievement of 25(OH)D level.
研究设计
- 研究类型
- Interventional
入排标准
- 年龄范围
- 18 Years 至 75 Years（—）
- 性别
- All
入选标准
- •1. Vitamin D deficiency; serum 25(OH)D level equal to or less than 30 ng/ml
- •2. Diabetes mellitus type 2 (evidence of glycated hemoglobin level (HbA1C) equal to or more than 6.5% or 2 of fasting plasma glucose equal to or more than 126 mg/dL).
排除标准
- •serum Calcium more than 10 mg/dL, serum Phosphorus more than 8 mg/dL, intact parathyroid hormone (iPTH) less than 15 ng/mL, or alkaline phosphatase (ALP) more than 3 times the upper normal limit, dialysis, kidney transplantation, peripheral arterial disease (radiologic findings or ankle-brachial index equal to or more than 0.9), active infection, pregnancy, and lactation, present or past malignancy, vitamin D (ergocalciferol or cholecalciferol) supplementation within the past 30 days, systolic blood pressure (BP) equal to or more than 160 mmHg or diastolic BP equal to or more than 100 mmHg, rheumatologic disease or loss to follow-up
研究者
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