Effects of prolonged exercise on metabolic changes in insulin, inflammation and oxidation in morbidly obese subjects

Not Applicable

• Conditions: Eutrophication; morbid obesity; C18.654.726.500.700; G16.500.285

• Registration Number: RBR-6frnzp
• Lead Sponsor: niversidade Estadual de Campinas

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Results First Posted: 1900-01-01
• Study Start: 2018-06-05
• Last Update Posted: 29 May 2023

Recruitment & Eligibility

• Status: Recruitment completed
• Sex: Not specified
• Target Recruitment: Not specified

Inclusion Criteria

Adults between 18 and 60 years of both sexes; availability and physical conditions to perform the tests and supervised physical exercises (control group and obese subjects submitted to physical exercise); availability to perform dietary restriction and physical inactivity (obese group submitted only to the restrictive diet) during the study period; inactive for at least 30 days (less than 150 minutes of moderate physical activity per week); no restrictive diet in the last 30 days; no use of medications for weight loss or modulation of body composition for at least 3 months; stable weight at least 3 months

Exclusion Criteria

Individuals with or having a first-degree history of cardiovascular diseas; hepatic impairmen; renal impairment; diabetes; thyroid disorders; menopausal women; pregnant women; nursing mothers; smokers; or in continuous use of any medications

Study & Design

• Study Type: Intervention
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Weight loss around 10% of the diet and exercise group of obesity in the pre and post intervention measurements;Reduction of the body fat percentage of both groups measured through the bioimpedance result pre and post intervention measurements;Improvement of biochemical parameters related to inflammation and oxidative stress (catalase, superoxide desmutase, glutathione, tumor necrosis factor, interleukin-6) in the pre and post intervention measurements;Reduced insulin resistance (HOMA-IR) pre and post intervention measurements

Secondary Outcome Measures

Name	Time	Method
Secondary outcomes are not expected