Technology Assisted Rehabilitation for Upper Limb Function in Myotonic Dystrophy Type 1

Not Applicable

Completed

• Conditions: Myotonic Dystrophy Type 1 (DM1)
• Interventions: Device: Tyromotion Amadeo and Armeo Senso

• Registration Number: NCT05560438
• Lead Sponsor: University of Oslo

Brief Summary

Myotonic Dystrophy type 1 (DM1) is a genetic multisystem disease causing muscle weakness and myotonia. As a result, upper limb function might become impaired. There are little research regarding rehabilitation and exercise for upper limb function in DM1. It is known from research on lower limb function in DM1 and other muscular dystrophies, that there are possibilities to improve function also in these deteriorating diseases. In this single subject experimental design study, 6-10 adults with DM1, who are at an inpatient rehabilitation center, will get intensive, but personally adapted senso- and robot assisted rehabilitation for arm- and hand function with Tyromotion Amadeo and Armeo Senso. These devices have previously been used in rehabilitation research for other neurological conditions. The participants will be followed up, and evaluated at a weekly basis, using video consultations. Fine motor skill dexterity test (9HPT) and the Nut and Bolt test will be used, and active range of motion (ROM) and muscle strenght and movement of upper limb will be measured. Furthermore, patient reported outcome measures (PROMS) on hand impairment and myotonia will be used, all with purpose to evaluate upper limb function.

Detailed Description

Not available

Study Timeline

• Study Start: 2022-01-03
• Study First Submitted: 2022-09-26
• Study First Submitted QC: 2022-09-26
• Study First Posted: 2022-09-29
• Primary Completion: 2023-12-31
• Study Completion: 2023-12-31
• Status Verified: 2024-05
• Last Update Submitted: 2024-05-13
• Last Update Posted: 2024-05-14

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 6

Inclusion Criteria

• Granted rehabilitation at Vikersund Rehabilitation center Genetical confirmed myotonic dystrophy diagnosis MIRS score between 2-5

Exclusion Criteria

• MIRS score on 1 Reduced Cognitive function and unable to participate in technological rehabilitation and digital evaluation

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: SINGLE_GROUP

Arm && Interventions

Group	Intervention	Description
Technorehab	Tyromotion Amadeo and Armeo Senso	Rehabilitation using Tyromotion Amadeo and Armeo Senso

Primary Outcome Measures

Name	Time	Method
Fine motor skill dexterity test, 9 hole peg test (9HPT)	1-3 minutes	Motor skill test

Secondary Outcome Measures

Name	Time	Method
Nut and Bolt test	5 minutes	Motor skill test
Pinch Gauge	5 minutes	Finger strength measures by Jamar digital pinch gauge
Hand strength	5 minutes	Measured by Jamar digital dynamometer
Range of motion (ROM)	5-10 minutes	Measure of ROM in upper limb joints

Trial Locations

Locations (1)

Vikersund Rehabilitation Center; 🇳🇴 Vikersund, Viken, Norway