Requirement of Propofol for Induction of Unconsciousness in Patients With Parkinson's Disease

Completed

• Conditions: Parkinson's Disease

• Registration Number: NCT01998204
• Lead Sponsor: Changhai Hospital

Brief Summary

Parkinson's disease (PD) is the second most prevalent neurodegenerative disease. The investigators clinical experience showed a trend of delayed emergence among patients undergoing deep brain stimulator (DBS) implantation and pulse generator placement under general anesthesia. Abnormal pharmacodynamics might be present among these patients, which had never been investigated.

Detailed Description

Not available

Study Timeline

• Study Start: 2012-01
• Primary Completion: 2013-06
• Study Completion: 2013-06
• Status Verified: 2013-11
• Study First Submitted: 2013-11-19
• Study First Submitted QC: 2013-11-23
• Last Update Submitted: 2013-11-23
• Study First Posted: 2013-11-28
• Last Update Posted: 2013-11-28

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 62

Inclusion Criteria

• Patients with Parkinson's disease undergoing deep brain stimulator implantation and pulse generator placement under general anesthesia
• non-Parkinsonian patients without Parkinson's disease undergoing intracranial surgery under general anesthesia

Exclusion Criteria

• ASA score higher than Class III
• predicted difficult airway
• hearing impairment
• inability to corporate with instruction
• alcohol or drug abuser
• patients refusing to provide informed consent

Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Consciousness status	Participants will be monitored during the period of propofol infusion, an expected average of less than 10 min	Consciousness status is evaluated by the observer's assessment of alertness and sedation score (OAA/S).

Trial Locations

Locations (1)

Department of Anesthesiology, Changhai Hospital; 🇨🇳 Shanghai, Shanghai, China