NL-OMON52454
Recruiting
Not Applicable
The effects of antipsychotic maintenance therapy on brain volume: randomized (dis)continuation after remission of a first psychotic episode. - HAMLETT MRI
Overview
- Phase
- Not Applicable
- Intervention
- Not specified
- Conditions
- Psychotic disorder / Schizophrenia
- Sponsor
- niversitair Medisch Centrum Groningen
- Enrollment
- 225
- Status
- Recruiting
- Last Updated
- 2 years ago
Overview
Brief Summary
No summary available.
Investigators
Eligibility Criteria
Inclusion Criteria
- •Inclusion criteria for FEP patients:
- •1\. The participant has had a first episode of psychosis and uses antipsychotic
- •medication.
- •2\. Psychotic symptoms are in remission for 3\-6 months with an antipsychotic.
- •3\. Age 18\-60 years.
- •4\. The participant understands the study and is able to provide written
- •informed consent.
- •5\. HAMLETT is the only medical\-scientific medication study in which the patient
- •participates.
- •6\. Sufficient command of the Dutch language.
Exclusion Criteria
- •Exclusion criteria for FEP patients:
- •1\. Dangerous or harmful behaviour occurred during the psychosis
- •2\. Coercive treatment (based on judicial ruling)
- •3\. The refusal to be informed of structural brain abnormalities that could be
- •detected during the experiment
- •4\. MRI contra\-indications, e.g. Ferrous objects in or around the body, or
- •claustrophobia
- •5\. Pregnancy
- •Exclusion criteria for healthy controls for the OCT\-scan:
- •1\. (History of) diagnosed psychiatric disorders
Outcomes
Primary Outcomes
Not specified
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