NL-OMON52454招募中不适用
The effects of antipsychotic maintenance therapy on brain volume: randomized (dis)continuation after remission of a first psychotic episode. - HAMLETT MRI
适应症
试验速览
- 阶段
- 不适用
- 状态
- 招募中
- 入组人数
- 225
研究概览
简要总结
暂无简介。
研究设计
- 研究类型
- Observational
入排标准
- 年龄范围
- 18 至 64（—）
入选标准
- •Inclusion criteria for FEP patients:
- •1. The participant has had a first episode of psychosis and uses antipsychotic
- •medication.
- •2. Psychotic symptoms are in remission for 3-6 months with an antipsychotic.
- •3. Age 18-60 years.
- •4. The participant understands the study and is able to provide written
- •informed consent.
- •5. HAMLETT is the only medical-scientific medication study in which the patient
- •participates.
- •6. Sufficient command of the Dutch language.
- •Inclusion criteria for healthy controls for OCT:
- •1. Age 18-60 years.
- •2. The participant understands the study and is able to provide written
- •informed consent.
排除标准
- •Exclusion criteria for FEP patients:
- •1. Dangerous or harmful behaviour occurred during the psychosis
- •2. Coercive treatment (based on judicial ruling)
- •3. The refusal to be informed of structural brain abnormalities that could be
- •detected during the experiment
- •4. MRI contra-indications, e.g. Ferrous objects in or around the body, or
- •claustrophobia
- •5. Pregnancy
- •Exclusion criteria for healthy controls for the OCT-scan:
- •1. (History of) diagnosed psychiatric disorders
- •2. (History of) psychotropic medication use
- •3. (History of) neurological diseases that may affect the brain
- •4. (History of) substance abuse
- •5. (History of) ophthalmological disorders, as determined with the
- •questionnaire on eye health ('Vragenlijst ooggezondheid*)
- •6. (History of) systemic and autoimmune diseases that may affect the eye or
- •optic nerve, e.g. diabetes, glaucoma or refractory arterial hypertension
- •7. First-degree family member with glaucoma
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