COVID - AirPollution

Completed

• Conditions: COVID-19 Mortality; COVID-19 Confirmed Cases

• Registration Number: NCT04463862
• Lead Sponsor: University Hospital, Strasbourg, France

Brief Summary

Epidemiological data have related particulate matter (PM), nitrogen dioxide (NO2) and ozone (O3) to COVID-19 morbidity and mortality at the population level. Air pollution may be related to an increase in the COVID-19 severity and lethality through its impact on chronic diseases such as cardiovascular and respiratory diseases and diabetes that are also the main comorbidities associated with COVID-19. Epidemiological studies using individual data are needed to provide more precise estimate of the association between air pollution exposure and COVID-19. In this multicenter prospective study, the investigators will analyze the number of deaths in COVID-19 confirmed cases in geriatric patients according to long-term exposure to air pollution, taking into account confounders such as diabetes, hypertension, age, and BMI. Exposure to air pollution will be estimated as the mean concentration of air pollutants at the residential address during the previous two years. In addition, the investigators will explore the relationship between short-term variations in air pollutants, relative humidity, temperature, UV radiations, pollen and the occurrence of COVID-19.

Detailed Description

Not available

Study Timeline

• Study Start: 2020-06-04
• Study First Submitted: 2020-07-08
• Study First Submitted QC: 2020-07-08
• Study First Posted: 2020-07-09
• Status Verified: 2021-06
• Primary Completion: 2021-06-01
• Study Completion: 2021-06-01
• Last Update Submitted: 2021-06-24
• Last Update Posted: 2021-06-25

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 660

Inclusion Criteria

• Patient over 60 years old (or dementia patient over 50 years old)
• Patient hospitalized in a geriatric department over the period from 2020/01/01 to 2020/06/01
• Patient who underwent RT-PCR SARS-CoV-2
• Patient (or trusted person/ legal guardian/curator, if applicable) who has given consent to the re-use of his/her data (patient data) for research purposes

Exclusion Criteria

None

Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
COVID-19 related-mortality	COVID-19 mortality between 2020/01/01 and 2020/06/01	Association between COVID-19 related-mortality and air pollutants concentrations estimated at the residential address of geriatric patients during the last 2 years ( from 2018/01/01 to 2019/12/31)

Secondary Outcome Measures

Name	Time	Method
COVID-19 confirmed cases	COVID-19 confirmed cases between 2020/01/01 and 2020/06/01	Association between short- term variations in air pollutants, temperature, humidity, UV, pollens and the occurrence of COVID-19 confirmed cases.; Short-term variations are defined as changes in air pollutants concentrations, temperature, humidity and pollen during the 20 days preceding the hospitalization.

Trial Locations

Locations (8)

Unité de soins palliatifs gériatriques, Centre Hospitalier Départemental de Bischwiller; 🇫🇷 Bischwiller, France

Unité de neurologie-gériatrie, Hôpital Erasme, Cliniques Universitaires de Bruxelles; 🇧🇪 Bruxelles, Belgium

Service de Gériatrie, Centre Hospitalier Départemental de Vendée; 🇫🇷 La Roche Sur Yon, France

Service de médecine aigüe gériatrique, Hôpital Nord Laennec, Hôpitaux Universitaires de Nantes; 🇫🇷 Nantes, France

Service de Gériatrie, Hôpitaux Bichat et Bretonnaux, Assistance Publique des Hôpitaux de Paris; 🇫🇷 Paris, France

Service de Médecine Interne et Gériatrie, Hôpitaux Universitaires de Reims; 🇫🇷 Reims, France

Service de Gériatrie, Hôpital de la Robertsau, Hôpitaux Universitaires de Strasbourg; 🇫🇷 Strasbourg, France

Service de médecine gériatrique, Hôpitaux Universitaires de Tours; 🇫🇷 Tours, France