Effects of Sea Buckthorn Oil on Dry Eye
- Conditions
- Dry Eye Syndromes
- Interventions
- Dietary Supplement: Sea buckthorn (Hippophaë rhamnoides) oilDietary Supplement: Placebo comparison
- Registration Number
- NCT00739713
- Lead Sponsor
- University of Turku
- Brief Summary
The objective is to study the effect of sea buckthorn oil on dry eye.
- Detailed Description
The objective is to study whether regular consumption of sea buckthorn berry oil can relieve the symptoms of dry eye syndrome. The study design is a parallel randomized double-blind placebo controlled trial. The participants daily consume sea buckthorn or placebo oil for 3 months. The dry eye symptoms will be monitored during the study using a validated questionnaire. In addition clinical dry eye tests are made by an ophthalmologist three time during the study. Samples will be taken for tear film lipid and cytokine analyses. Blood samples for the analyses of inflammatory markers are also obtained. The cytokine and other inflammation marker analyses are optional. The symptoms will be monitored and clinical tests made also 4 weeks after the participants have stopped consuming the study oils.
Recruitment & Eligibility
- Status
- COMPLETED
- Sex
- All
- Target Recruitment
- 100
- Dry eye symptoms
- Severe illness
- Anticholinergic drugs
- Smoking
Study & Design
- Study Type
- INTERVENTIONAL
- Study Design
- PARALLEL
- Arm && Interventions
Group Intervention Description SB Sea buckthorn (Hippophaë rhamnoides) oil Sea buckthorn oil group PL Placebo comparison Placebo group
- Primary Outcome Measures
Name Time Method Symptom severity: symptom questionnaires and clinical dry eye tests 3 months intervention + 1 month after the intervention
- Secondary Outcome Measures
Name Time Method Tear film lipid profile, tear cytokines, inflammation mediators in blood 3 months intervention + 1 month after the intervention
Trial Locations
- Locations (1)
University of Turku
🇫🇮Turku, Finland