Acute Lung Injury - improving functional outcomes in survivors

Not Applicable

• Conditions: Acute Lung Injury; Respiratory - Other respiratory disorders / diseases

• Registration Number: ACTRN12611000298910
• Lead Sponsor: Jennifer Mackney

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Results First Posted: 1900-01-01
• Study Start: 2011-03-21
• Study Completion: 2014-10-01
• Last Update Posted: 13 January 2020

Recruitment & Eligibility

• Status: Stopped early
• Sex: All
• Target Recruitment: 7

Inclusion Criteria

Patients will be screened from the point of admission to the ICU, on a daily basis by the unit’s dedicated research nurse, to identify suitability for the study. Inclusion criteria will comprise; (i) age > 18 years and, (ii) meet the American-European Consensus Conference criteria for ALI (iii) intubation and ventilation for > 4 days.

Exclusion Criteria

Exclusion criteria will comprise the presence of any neurological or musculoskeletal condition likely to adversely affect the ability to mobilise safely or to follow commands. This includes; immobility prior to admission, history of recent major pulmonary resection, documented neurological disease including traumatic brain injury, poorly managed psychiatric disorders, diagnosis or treatment for malignant cancer within preceding 12 months, orthopaedic injuries with mobility restrictions, and inability to understand English.

Study & Design

• Study Type: Interventional
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Peak VO2 will be assessed via a gas analysis system during a cardiopulmonary exercise test (CPET). The CPET allows a detailed analysis of the cardiac and pulmonary responses to a progressive increase in power on a cycle ergometer. Blood lactate concentration during exercise will be measured in a small drop of blood obtained following a puncture of the finger tip using a lancet.[The patient will complete a CPET 1 week prior to commencing the intervention or control and 1 week after completing the intervention or control. The first CPET will be conducted within 4-6 weeks of discharge from an acute care facility.]