Elicitation of Steady-state Audiovisual Responses in 6- and 10-month-old Infants

Not Applicable

Not yet recruiting

• Conditions: Speech
• Interventions: Behavioral: Magnetoencephalography (MEG); Other: Cognition development questionnaire

• Registration Number: NCT06282289
• Lead Sponsor: Institut Pasteur

Brief Summary

The goal of this study is to investigate the preferential responses of speech neural systems in infants.

The main question it aims to answer is to determine whether the oscillatory synchronization capacity is associated with children's language level (i.e. vocabulary).

Participants will be presented with synthetically modulated stimuli at three frequency scales: 4 Hz, 5 Hz and 30 Hz.

Detailed Description

Not available

Study Timeline

• Study First Submitted: 2023-12-18
• Study First Submitted QC: 2024-02-20
• Study First Posted: 2024-02-28
• Status Verified: 2025-02
• Last Update Submitted: 2025-02-28
• Last Update Posted: 2025-03-03
• Study Start: 2025-05
• Primary Completion: 2025-09-21
• Study Completion: 2025-09-21

Recruitment & Eligibility

• Status: NOT_YET_RECRUITING
• Sex: All
• Target Recruitment: 64

Inclusion Criteria

• be 6 or 10 months old (+/- 2 weeks)
• have received age-appropriate information on the experiment
• their legal guardians have received appropriate information and given their oral consent.

Exclusion Criteria

• A neurological disorder (visual, auditory, motor, executive)
• Developmental delay

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: PARALLEL

Arm && Interventions

Group	Intervention	Description
6-month-old infants	Magnetoencephalography (MEG)	-
6-month-old infants	Cognition development questionnaire	-
10-month-old infants	Cognition development questionnaire	-
10-month-old infants	Magnetoencephalography (MEG)	-

Primary Outcome Measures

Name	Time	Method
Significance of correlation between the delta (i.e. difference) of synchronization power estimated at 10- and 6-months of age and the delta of vocabulary level measured at 18months of age.	at 10-months, 6-months and 18-months of age

Secondary Outcome Measures

Name	Time	Method
The equation for linear regression analysis used to estimate the amount of neuronal synchronization between auditory and visual perception systems according to the Coherence and the Synchrony of AV inputs	at 10- and 6-months of age
The equation for linear regression analysis used to estimate the variation in the amount of neuronal synchronization between 4 experimental conditions according to the Coherence and the Synchrony of AV inputs	at 10- and 6-months of age	4 experimental conditions : AV synchronous coherent, AV asynchronous coherent, AV synchronous incoherent, and AV asynchronous incoherent