Monitor Immune Microenvironment and systemic immune effects in pediatric Brain tumors
Recruiting
- Conditions
- Pediatric brain tumors
- Registration Number
- NL-OMON24486
- Lead Sponsor
- Princess Máxima Center for Pediatric Oncology
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Recruiting
- Sex
- Not specified
- Target Recruitment
- 60
Inclusion Criteria
Age 0 – 18 years at inclusion
- Newly diagnosed brain tumor or relapse of a brain tumor
- MRI representing an image of a high grade brain tumor (high grade glioma, ependymoma, ATRT, medulloblastoma, or otherwise high grade) OR CNS tumor where based on MRI images the judgement of high grade versus low grade can’t be made. NB in case MRI imaging prior to biopsy and/or resection is not feasible, the patient can be included based on CT imaging and clinical assessment
- Clinical indication for tumor biopsy/resection
- Written (parental) informed consent
Exclusion Criteria
- Suspected germ cell tumor on radiology or based on tumor markers (aFP, ßHCG)
- Suspected craniopharyngioma on radiology
- Clear characteristics of low grade tumor
Study & Design
- Study Type
- Observational non invasive
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method Descriptive characterisation of lymphoid and myeloid subsets and activation status in different compartment, e.g. tumor microenvironment, blood, bone marrow, and CSF at different timepoints
- Secondary Outcome Measures
Name Time Method Descriptive characterisation of lymphoid and myeloid subsets and activation status in different compartment, e.g. tumor microenvironment, blood, bone marrow, and CSF before after and during treatment<br><br>Multivariate regression analysis of lymphoid and myeloid subsets and activation status in the different compartments in relation to overall survival and event free survival (event = relapse or death of any cause) response to therapy