Aspects of Self-harm - Cognition, Imaging and Treatability
- Conditions
- Non-Suicidal Self InjuryPersonality DisordersSelf-Harm, DeliberateAttempt Suicide
- Interventions
- Diagnostic Test: Emotional Stop Signal TaskDiagnostic Test: Magnetic Resonance ImagingOther: World Health Organizations Disability Assessment Schedule (WHODAS 2.0)Diagnostic Test: Personality Inventory for DSM-5 (PID-5)Diagnostic Test: Stop Signal Task (CANTAB)Diagnostic Test: Intra-Extra Dimensional Set Shift (CANTAB)Diagnostic Test: Spatial Working Memory Test (CANTAB)Diagnostic Test: Multitasking Test (CANTAB)Diagnostic Test: Cambridge Gambling Task Test
- Registration Number
- NCT04905797
- Lead Sponsor
- Region Skane
- Brief Summary
Deliberate self-harm (DSH) is a common symptom in psychiatric disorders. This study aim at increased understanding of parameters associated with DSH with the long term goal to potentially improve and possibly personalise its treatment.
In short, the study will characterise cognitive, psychiatric and demographic factors with focus on executive function and will compare results from individuals with DSH, individuals who have ceased DSH as well as psychiatric patients without DSH and individuals who never engaged in DSH. Adequate statistical tests will be used to compare groups.
Participants will be interviewed by a trained physician for basic medical history, history of self-harm and treatment for that, demographic data and diagnostic evaluation. Thereafter the participants will undergo standardised neuropsychological testing focusing on emotional response inhibition, decision making and risk taking, attention set shifting, working memory, inhibition and planning. Some participants will redo parts of this testing during fMRI, as well as undergo DTI and volumetry.
- Detailed Description
Deliberate self-harm (DSH) is a common symptom in psychiatric disorders. Today, there is not sufficient knowledge as to why an individual continues to suffer from DSH, DSH is reduced or even ceased - regardless given treatment or not. The overall aim of this project is to characterise cognitive, psychiatric and demographic factors as well as perform brain imaging in individuals currently suffering from DSH, individuals with a prior history of DSH, individuals with psychiatric disease but no DSH and healthy individuals. The intention is to gain more knowledge on factors associated with DSH and thereby potentially improve and possibly personalize treatment.
The following hypotheses will be tested:
Individuals currently suffering from DSH have lower scores on executive function than individuals with a prior history of DSH, individuals with psychiatric disease but no DSH and healthy individuals.
Individuals currently suffering from DSH have lower level daily life functioning and more severe psychiatric symptoms than individuals with a prior history of DSH, individuals with psychiatric disease but no DSH and healthy individuals.
Individuals currently suffering from DSH have higher scores of negative affectivity, lower scores of antagonism and lower scores of disinhibition measured with Personality Inventory for DSM-5 than individuals with a prior history of DSH, individuals with psychiatric disease but no DSH and healthy individuals.
Individuals currently suffering from DSH have, when executing the neurocognitive tests in hypothesis 1, a significant lower blood flow in the prefrontal network, than individuals with a prior history of DSH, individuals with psychiatric disease but no DSH and healthy individuals.
Individuals currently suffering from DSH have a decrease in local cerebral white matter compared to individuals with a prior history of DSH, individuals with psychiatric disease but no DSH and healthy individuals.
Material:
The aim is to recruit 300 participants in total, 75 participants to each group:
1. individuals with psychiatric disorders and persistent DSH
2. individuals with psychiatric disorders who have ceased DSH
3. individuals with psychiatric disorders who never had DSH
4. healthy controls who never had DSH
Participants will be interviewed by a trained physician for basic medical history, history of self-harm and treatment for that, demographic data and diagnostic evaluation. Thereafter the participants will undergo standardised neuropsychological testing focusing on emotional response inhibition, decision making and risk taking, attention set shifting, working memory, inhibition and planning. Some participants will redo parts of this testing during fMRI, as well as undergo DTI and volumetry.
Recruitment & Eligibility
- Status
- RECRUITING
- Sex
- All
- Target Recruitment
- 300
Not provided
Not provided
Study & Design
- Study Type
- OBSERVATIONAL
- Study Design
- Not specified
- Arm && Interventions
Group Intervention Description Clinical cases who ceased self-harm Magnetic Resonance Imaging Individuals with psychiatric disorders who have ceased DSH Deliberate self-harm Magnetic Resonance Imaging Individuals with psychiatric disorders and persistent DSH Deliberate self-harm Emotional Stop Signal Task Individuals with psychiatric disorders and persistent DSH Deliberate self-harm Personality Inventory for DSM-5 (PID-5) Individuals with psychiatric disorders and persistent DSH Deliberate self-harm Stop Signal Task (CANTAB) Individuals with psychiatric disorders and persistent DSH Deliberate self-harm World Health Organizations Disability Assessment Schedule (WHODAS 2.0) Individuals with psychiatric disorders and persistent DSH Deliberate self-harm Multitasking Test (CANTAB) Individuals with psychiatric disorders and persistent DSH Clinical cases who ceased self-harm World Health Organizations Disability Assessment Schedule (WHODAS 2.0) Individuals with psychiatric disorders who have ceased DSH Clinical cases with no self-harm Cambridge Gambling Task Test Individuals with psychiatric disorders who never had DSH Healthy controls Emotional Stop Signal Task Healthy controls who never had DSH Deliberate self-harm Spatial Working Memory Test (CANTAB) Individuals with psychiatric disorders and persistent DSH Deliberate self-harm Cambridge Gambling Task Test Individuals with psychiatric disorders and persistent DSH Clinical cases who ceased self-harm Emotional Stop Signal Task Individuals with psychiatric disorders who have ceased DSH Clinical cases who ceased self-harm Personality Inventory for DSM-5 (PID-5) Individuals with psychiatric disorders who have ceased DSH Deliberate self-harm Intra-Extra Dimensional Set Shift (CANTAB) Individuals with psychiatric disorders and persistent DSH Clinical cases who ceased self-harm Stop Signal Task (CANTAB) Individuals with psychiatric disorders who have ceased DSH Clinical cases who ceased self-harm Intra-Extra Dimensional Set Shift (CANTAB) Individuals with psychiatric disorders who have ceased DSH Clinical cases who ceased self-harm Multitasking Test (CANTAB) Individuals with psychiatric disorders who have ceased DSH Clinical cases who ceased self-harm Cambridge Gambling Task Test Individuals with psychiatric disorders who have ceased DSH Clinical cases with no self-harm Personality Inventory for DSM-5 (PID-5) Individuals with psychiatric disorders who never had DSH Clinical cases who ceased self-harm Spatial Working Memory Test (CANTAB) Individuals with psychiatric disorders who have ceased DSH Clinical cases with no self-harm World Health Organizations Disability Assessment Schedule (WHODAS 2.0) Individuals with psychiatric disorders who never had DSH Healthy controls World Health Organizations Disability Assessment Schedule (WHODAS 2.0) Healthy controls who never had DSH Healthy controls Stop Signal Task (CANTAB) Healthy controls who never had DSH Clinical cases with no self-harm Emotional Stop Signal Task Individuals with psychiatric disorders who never had DSH Clinical cases with no self-harm Magnetic Resonance Imaging Individuals with psychiatric disorders who never had DSH Clinical cases with no self-harm Stop Signal Task (CANTAB) Individuals with psychiatric disorders who never had DSH Clinical cases with no self-harm Intra-Extra Dimensional Set Shift (CANTAB) Individuals with psychiatric disorders who never had DSH Clinical cases with no self-harm Multitasking Test (CANTAB) Individuals with psychiatric disorders who never had DSH Healthy controls Magnetic Resonance Imaging Healthy controls who never had DSH Healthy controls Intra-Extra Dimensional Set Shift (CANTAB) Healthy controls who never had DSH Clinical cases with no self-harm Spatial Working Memory Test (CANTAB) Individuals with psychiatric disorders who never had DSH Healthy controls Personality Inventory for DSM-5 (PID-5) Healthy controls who never had DSH Healthy controls Spatial Working Memory Test (CANTAB) Healthy controls who never had DSH Healthy controls Multitasking Test (CANTAB) Healthy controls who never had DSH Healthy controls Cambridge Gambling Task Test Healthy controls who never had DSH
- Primary Outcome Measures
Name Time Method Executive functioning Up to 1 hour Scores on cognitive tests measuring executive functioning
Volumetry Up to 1 hour Volumes of local cerebral white matter
Level of function in daily life 30 days Scores on WHODAS 2.0
Personality traits More than 1 year (stable) Scores on Personality Inventory for DSM-5
Blood flow Up to 1 hour Blood flow in prefrontal cortex during neurocognitive tests
- Secondary Outcome Measures
Name Time Method
Trial Locations
- Locations (1)
Psykiatri och habilitering, Region SkĂĄne
🇸🇪Lund, Skåne, Sweden