Aerosolised Colistin for Treating Ventilator Associated Pneumonia.
Not Applicable
- Conditions
- Health Condition 1: J159- Unspecified bacterial pneumonia
- Registration Number
- CTRI/2021/07/034866
- Lead Sponsor
- Dr Supradip Ghosh
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Open to Recruitment
- Sex
- Not specified
- Target Recruitment
- 0
Inclusion Criteria
1.New onset of fever ( >100.4°F) with or without leukopenia (<=4000 WBC/mm3) or leukocytosis (>=12,000 WBC/mm3)
2.New onset of purulent sputum/change in character of sputum/increased respiratory secretions and/or worsening gas exchange
3.Radiological (Chest X-ray or CT Chest) evidence of consolidation.
4.Being on invasive mechanical ventilation anytime within past 48-hours.
Exclusion Criteria
1.Patients <18 years of age
2.Pregnant ladies
3.Refusal of consent
4.Patient already on intravenous polypeptide antibiotics for some other indication or requiring intravenous polypeptide administration for suspicion of other nosocomial infections
5.Known hypersensitivity to Colistin.
Study & Design
- Study Type
- Interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method â?¢Clinical response rate of intravenous polymyxin B plus aerosolized colistin compared to intravenous polymyxin B alone amongst study subject.Timepoint: At the end of treatment period
- Secondary Outcome Measures
Name Time Method ilTimepoint: Not Applicable