Observational Study Assessing the Diagnostic Contribution of 3-Tesla MRI, CSF Analysis and a Second Opinion in a Specialized Movement Disorder Centre, in Differentiating Between Parkinson's Disease and Atypical Parkinsonism
Overview
- Phase
- Not Applicable
- Intervention
- Not specified
- Conditions
- Parkinson's Disease
- Sponsor
- Radboud University Medical Center
- Enrollment
- 150
- Locations
- 1
- Primary Endpoint
- percentage of correct diagnosis for each of the specified ancillary investigations
- Last Updated
- 10 years ago
Overview
Brief Summary
Background:
Parkinson's Disease and the Atypical Parkinsonian Disorder (like Multiple System Atrophy, Progressive Supranuclear Palsy, Corticobasal Degeneration, Lewy Body Dementia) are disease entities with partly common symptomatology. Especially very early in the course of disease, the differentiation between both disease entities can be challenging, even for specialists in the field of movement disorder. However, the establishment of a correct diagnosis is very important for adequate patientcounseling, treatment and the correct inclusion of patients in research trials. Ancillary diagnostic investigations are looked upon to aid in this diagnostic dilemma.
Objective:
To investigate the value of ancillary diagnostic investigations, more specific MRI, analysis of cerebrospinal fluids and a second opinion in a specialized movement disorder centre, to differentiate Parkinson's disease and the Atypical Parkisonisonian disorder.
Investigators
Marjolein Aerts
dr. M.B. Aerts
Radboud University Medical Center
Eligibility Criteria
Inclusion Criteria
- •Hypokinetic rigid syndrome
- •Disease duration of maximum 36 months
Exclusion Criteria
- •Probable diagnosis of PD without any red flags
- •Probable diagnosis MSA
- •Probable diagnosis PSP
- •Diagnosis CBD
- •Diagnosis DLB
- •Probable diagnosis Vascular Parkinsonism
- •Other neurodegenerative disease than parkinsonism
- •A prior history of brain surgery
- •Instable comorbidity
Outcomes
Primary Outcomes
percentage of correct diagnosis for each of the specified ancillary investigations
Time Frame: 36 months
Percentage of correct diagnosis for each of the specified ancillary investigations to differentiate between either PD or atypical parkinsonism
Secondary Outcomes
- Percentage of correct diagnosis for each of the specified ancillary investigations(36 months)