Optimization of the Acquisition Sequence to Improve the Quality and Comfort of Magnetic Resonance Imaging Exam

Not Applicable

Recruiting

• Conditions: Healthy Subjects; Patient Performing an MRI Examination
• Interventions: Other: MRI examination

• Registration Number: NCT04645628
• Lead Sponsor: Central Hospital, Nancy, France

Brief Summary

The purpose of this study is to evaluate the optimization of MRI acquisition sequences.

Detailed Description

Not available

Study Timeline

• Study First Submitted: 2020-11-16
• Study First Submitted QC: 2020-11-20
• Study First Posted: 2020-11-27
• Study Start: 2020-12-04
• Status Verified: 2025-02
• Last Update Submitted: 2025-02-18
• Last Update Posted: 2025-02-19
• Primary Completion: 2025-12-03
• Study Completion: 2025-12-03

Recruitment & Eligibility

• Status: RECRUITING
• Sex: All
• Target Recruitment: 720

Inclusion Criteria

Not provided

Exclusion Criteria

Not provided

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: SINGLE_GROUP

Arm && Interventions

Group	Intervention	Description
All subjects will have an MRI examination	MRI examination	-

Primary Outcome Measures

Name	Time	Method
Image quality based on standard imaging quality criteria.	6 months after the last inclusion	The image quality will be appreciated visually at least by a radiologist or a researcher.

Secondary Outcome Measures

Name	Time	Method
Comparison of the Signal to Noise Ratio obtained by the optimized MRI sequence and the reference situation (standard sequence).	6 months after the last inclusion	Signal to Noise Ratio will be measured in arbitrary units.
Evaluation of intra-subject reproducibility on the same MRI and on two MRIs.	6 months after the last inclusion	Measurement of intra-subject reproducibility on the same MRI and on two MRIs by the intra-class correlation coefficient for quantitative measurement or by the kappa coefficient for a qualitative measurement.
Comparison of the Contrast to Noise Ratio obtained by the optimized MRI sequence and the reference situation (standard sequence).	6 months after the last inclusion	Contrast to Noise Ratio will be measured in arbitrary units.
Comparison of blurring and artefacts obtained by the optimized MRI sequence and the reference situation (standard sequence).	6 months after the last inclusion	Absence of blurring and artefacts will be assessed by at least one radiologist according to an ordinal scale.
Comparison of the spatial resolution obtained by the optimized MRI sequence and the reference situation (standard sequence).	6 months after the last inclusion	Spatial resolution will be measured in mm².
Qualification of the MRI acquisition for a clinical study.	6 months after the inclusion	Validation of MRI acquisition by a centralized review center.
Comparison of the acquisition time obtained with the optimized MRI sequence and the reference situation (standard sequence).	6 months after the last inclusion	Time acquisition will be evaluated in minutes.

Trial Locations

Locations (1)

CHRU de Nancy; 🇫🇷 Nancy, France