Evaluation of the Elasticity of the Mitral Valve Chordae by Uniaxial Traction in the Context of Mitral Valve Regurgitation With a Comparison of the Results: Mitral Valve Prolapse vs Restriction of Mitral Valve Movement
试验速览
- 阶段
- 不适用
- 状态
- 招募中
- 入组人数
- 30
- 试验地点
- 1
- 主要终点
- Maximum value of Young's modulus
研究概览
简要总结
There is no information in the literature on the mechanobiological characteristics of mitral valve chords in living humans. All examinations were carried out on tissues taken from animals, either from cadavers or from frozen human tissues. The objective is to determine mechanobiological and histological characteristics of the mitral valve chords in living humans, as well as to compare differences in elasticity in different groups (Group A: patients with mitral valve prolapse versus Group B: patients with restrictive ischemic mitral valve).
详细描述
The prospective study will be conducted on 20 patients, who will be selected consecutively without randomization. The inclusion and exclusion criteria are determined.
The harvested tissue will not be frozen and will kept in natural conditions as close as possible.
研究设计
- 研究类型
- Observational
- 观察模型
- Cohort
- 时间视角
- Prospective
入排标准
- 年龄范围
- 45 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •All patients programmed for mitral valve replacement who have more than 45 years old
排除标准
- •Patients with mitral calcification
- •Mitral valve rheumatic disease
- •Mitral valve infections
- •Redo surgery on the mitral valve
结局指标
主要结局
Maximum value of Young's modulus
时间窗: Hour 1
Comparison of elasticity difference between the two groups
次要结局
- First histological evaluation(Hour 1)