Ex vivo evaluation of the anti-fibrotic effect of CD26/DPP4 inhibition after lung transplantation in a spheroid cell culture model
Recruiting
- Conditions
- Patients undergoing bronchoscopy with transbronchial biopsy in the Department of Pneumology at the University Hospital Freiburg. This includes patients after lung transplantation (single or double lung transplantation) who undergo surveillance bronchoscopy.
- Registration Number
- DRKS00031135
- Lead Sponsor
- niversitätsklinikum Freiburg, Klinik für Thoraxchirurgie
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Recruiting
- Sex
- All
- Target Recruitment
- 150
Inclusion Criteria
Patients undergoing bronchoscopy with transbronchial biopsy in the Department of Pneumology at the University Hospital Freiburg. This includes patients after lung transplantation (single or double lung transplantation) who undergo surveillance bronchoscopy.
Exclusion Criteria
none
Study & Design
- Study Type
- observational
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method - Establishment of an ex vivo spheroid cell culture model from transbronchial biopsies.<br>- Evaluation of the antifibrotic effect of CD26/DPP4 inhibition in pulmonary tissue after lung transplantation in this model. <br>
- Secondary Outcome Measures
Name Time Method - Evaluation of CD26/DPP4 expression and cellular composition of the obtained spheroid cell cultures.<br>- Correlation of the fibrotic potential of the spheroid cell culture with chronic lung allograft dysfunction (CLAD)-free and overall survival<br>