Association of end-stage renal disease with the prognosis and hemostasis of patients with atrial flimmern or coronary heart disease
Recruiting
- Conditions
- chronic kidney diseaseatrial fibrillationcoronary heart disease
- Registration Number
- DRKS00033035
- Lead Sponsor
- niversitätsklinikum Freiburg
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Recruiting
- Sex
- All
- Target Recruitment
- 238
Inclusion Criteria
• Patients over 18 years old with chronic kidney insufficiency from stage IV according to KDIGO
• known atrial fibrillation and/or coronary heart disease
• Stable kidney retention parameters
• consistent administration of anticoagulants/platelet aggregation inhibitors and no medication change for at least 1 week, or no anticoagulants/platelet aggregation inhibitors due to high bleeding risk.
Exclusion Criteria
• Pregnant
• Patients with known coagulation disorders, liver insufficiency, or active cancer disease
• Acute kidney failure in the current hospital stay
• Severe thrombocytopenia (< 100,000/µl) or thrombocytosis (> 450,000/µl)
• Noncompliance, lack of consistent medication intake
Study & Design
- Study Type
- observational
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method AF-study: combined endpoint with bleeding and all-cause-death<br>CAD-study: combined endpoint with MACE (apoplex, myocardial infarction, all-cause-death)
- Secondary Outcome Measures
Name Time Method AF-study: coagulation parameters (anti-factor-Xa activity, PPT, INR), apoplex, myocadial infarction<br>CAD-study: platelet function, bleeding