Problems With Immune Recovery in the Gut Tissue
Completed
- Conditions
- Human Immunodeficiency Virus
- Registration Number
- NCT01460433
- Lead Sponsor
- University of Minnesota
- Brief Summary
The aim of this study is to find out if the process of HIV replication in the lymph tissue and gut tissue of people taking HIV drugs causes long-term damage to the ability of the gut to protect you from other infections and health problems.
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- COMPLETED
- Sex
- All
- Target Recruitment
- 21
Inclusion Criteria
HIV+ individuals
- Seropositive for HIV
- On ART for at least 12 months
- Seropositive for Herpes Simplex Type 2 and Cytomegalovirus
- Age ≥ 18 years
- Negative pregnancy test for eligible women of childbearing potential
HIV- individuals
- Seronegative for HIV
- Seropositive for Herpes Simplex Type 2 and Cytomegalovirus
- Age ≥ 18 years
- Negative pregnancy test for eligible women of childbearing potential
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Exclusion Criteria
- Taking daily suppressive therapy for Herpes Simplex Type 2
- Contraindication to surgical & endoscopic procedures (as judged by PI)
- Psychiatric or psychological illness that would make adherence to protocol procedures unlikely
- Pregnancy
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Study & Design
- Study Type
- OBSERVATIONAL
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method Herpes Simplex Virus - Type 2 shed rate 60 days
- Secondary Outcome Measures
Name Time Method Evidence of HIV replication in blood and lymphoid tissue 60 days
Trial Locations
- Locations (1)
University of Minnesota
🇺🇸Minneapolis, Minnesota, United States