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临床试验/NCT05838612
NCT05838612已完成不适用

Short-term Warm Water Immersion as a Heat Acclimation Strategy to Enhance Heat Dissipation in Older Adults: An Exploratory Study

University of Ottawa2 个研究点 分布在 1 个国家目标入组 12 人开始时间: 2022年4月29日最近更新:
适应症

试验速览

阶段
不适用
状态
已完成
入组人数
12
试验地点
2
主要终点
Evaporative heat loss

研究概览

简要总结

Aging is associated with impairments in heat loss responses of skin blood flow and sweating leading to reductions in whole-body heat loss. Consequently, older adults store more body heat and experience greater elevations in core temperature during heat exposure at rest and during exercise. This maladaptive response occurs in adults as young as 40 years of age. Recently, heat acclimation associated with repeated bouts of exercise in the heat performed over 7 successive days has been shown to enhance whole-body heat loss in older adults, leading to a reduction in body heat storage. However, performing exercise in the heat may not be well tolerated or feasible for many older adults. Passive heat acclimation, such as the use of warm-water immersion may be an effective, alternative method to enhance heat-loss capacity in older adults. Thus, the following study aims to assess the effectiveness of a 7-day warm-water immersion (~40°C) protocol in enhancing whole-body heat loss in older adults. Warm-water immersion will consist of a one-hour immersion in warm water with core temperature clamped at 38.5°C. Improvements in whole-body heat loss will be assessed during an incremental exercise protocol performed in dry heat (i.e., 40°C, ~15% relative humidity) prior to and following the 7-day passive heat acclimation protocol. The incremental exercise protocol will consist of three 30 minute exercise bouts performed at increasing fixed rates of metabolic heat production (i.e., 150, 200, and 250 W/m2), each separated by 15-minutes of recovery, with exception final recovery will be 1-hour in duration) performed in a direct calorimeter (a device that provides a precise measurement of the heat dissipated by the human body).

研究设计

研究类型
Interventional
分配方式
Na
干预模型
Single Group
主要目的
Basic Science
盲法
None

盲法说明

Data will be blinded prior to analysis.

入排标准

年龄范围
60 Years 至 80 Years(Adult, Older Adult)
性别
Male
接受健康志愿者

入选标准

  • Elderly (60-80 years), non-smoking adults.
  • Not engaged in regular physical activity (>2 sessions/week for ≥20 minutes per session).
  • Willing to provide informed consent.
  • Healthy, no diagnosed health conditions.
  • Body Mass index (BMI) <35 kg/m2.

排除标准

  • Heat adapted due to repeated exposure to hot environments within the last 3 weeks (use sauna, recent travel to hot climates, other).

结局指标

主要结局

Evaporative heat loss

时间窗: End of 30 minute bout 3 (average of last 5 minutes).

Evaporative heat loss as assessed using a direct air calorimeter.

Whole-body heat loss

时间窗: End of 30 minute exercise bout 3 (average of last 5 minutes).

The sum of evaporative and dry heat exchange will be quantified during each exercise period (i.e., 150, 200 and 250 W/m2).

次要结局

  • Core temperature(End of 30 minute exercise bout 3 (average of last 5 minutes).)
  • Skin temperature(End of 30 minute exercise bout 3 (average of last 5 minutes).)
  • Thermal comfort scale(End of 30 minute exercise bout 3 (average of last 5 minutes).)
  • Thirst sensation scale(End of 30 minute exercise bout 3 (average of last 5 minutes).)
  • Dry heat loss(End of 30 minute exercise bout 3 (average of last 5 minutes).)
  • Thermal sensation scale(End of 30 minute exercise bout 3 (average of last 5 minutes).)
  • Body heat content(Change from start to end of 30 minute exercise bout 2)
  • Change in core temperature(Change from baseline resting to end of end of 30 minute exercise bout 3.)
  • Heart rate(End of 30 minute exercise bout 3 (average of last 5 minutes).)
  • Body heat storage(Change from start to end of 30 minute exercise bout 3)
  • Heart rate variability(End of 30 minute exercise bout 3 (average of last 5 minutes).)
  • Cumulative body heat storage(Change from baseline resting to end of exercise bout 3)
  • Change in skin temperature(Change from baseline resting to end of end of 30 minute exercise bout 3.)
  • Rating of perceived exertion(End of 30 minute exercise bout 3 (average of last 5 minutes).)

研究者

申办方类型
Other
责任方
Principal Investigator
主要研究者

Glen P. Kenny

Full Professor, University Research Chair, Principal Investigator

University of Ottawa

研究点 (2)

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