TCTR20170508003尚未招募1 期
Comparison of ocular surface in non-exophthalmic Graves’ disease who had different thyroid status (hyperthyroid, euthyroid) with normal population
Department of Ophthalmology, Faculty of Medicine, Siriraj Hospital, Mahidol university0 个研究点目标入组 90 人开始时间: 2017年5月8日最近更新:
适应症
试验速览
- 阶段
- 1 期
- 状态
- 尚未招募
- 发起方
- 入组人数
- 90
研究概览
简要总结
暂无简介。
研究设计
- 研究类型
- Observational
入排标准
- 年龄范围
- 18 Years 至 65 Years（—）
- 性别
- All
入选标准
- •Group 1 : Graves' disease with biochemical of hyperthyroid
- •1.History of diagnosis of Graves' disease
- •2.History of laboratory investigation that shown low TSH level at least 1 time after diagnosed as Graves' disease
- •3.Had thyroid function test : T3 or FT3 and T4 or FT4 level within 1 week and results shown high level of T3 or FT3 or T4 or FT4 level
- •Group2 : Graves' disease with biochemical of euthyroid
- •1.History of diagnosis of Graves' disease
- •2.History of laboratory investigation that shown low TSH level at least 1 time after diagnosed as Graves' disease
- •3.Had thyroid function test : T3 or FT3 and T4 or FT4 level within 1 week and results of T3 or FT3 and T4 or FT4 level are all within normal limit
- •Group3 : Control group
- •1.No symptoms of thyroid disease and no previous diagnosis of thyroid disease
- •2.No family history of thyroid disease
排除标准
- •1.Age <18 year or male age >65 year or female age > 55 year
- •2.Proptosis from Hertel exopthalmometer
- •2.1 Enlargement of eye >20mm or 2.2 Different size of 2 eyes > 2mm
- •3.Previous diagnosed as dry eye
- •4.Previous diagnosed as allergic conjunctivitis
- •5.Previous diagnosed as Sjogren syndrome
- •6.Previous diagnosed as glaucoma and used anti-glaucomatic drug
- •7.Eye infection or red eye
- •8.History of lid, conjunctiva, pterygium or ocular surgery
- •9.History of eye prosthesis
- •10.History of contact lens wear 1 month before
- •11.History of HIV or autoimmune deficiency disease
- •12.History of heapatitis C infection and receive anti-viral treatment
- •13.Previous diagnosed as rheumatoid arthritis
- •14.History of iodine131 ablation (I-131)
- •15.History of use antihistamine within 2 weeks
- •16.Eye examination reveals lid lag or lid retraction in one or both eyes
- •17.Vulnerable subject e.g. Inpatient case, emergency case, immigrant, pregnancy etc.
研究者
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