Effect Of Dantyadi Kashaya Yoni Prakshalana in Shweta Pradara with special reference to Candida vaginitis
- Conditions
- Candidiasis of vulva and vagina. Ayurveda Condition: SLAISHMIKA-ASRUGDARAH,
- Registration Number
- CTRI/2023/10/059311
- Lead Sponsor
- Dr Nikita M Magennavar
- Brief Summary
· Abnormal vaginaldischarge is a frequent complaint of women seen in the gynecologic clinic. Thedischarge may range from excess of normal to one which is a part of widespectrum of diseases. Candidavaginitis is caused by *Candida albicans* a gram - positive yeast like fungus. The patientcomplains of vaginal discharge with intense vulvovaginal pruritis. In *Ayurveda,* the word *Shwetapradara* has not appeared in the *BruhatTrayis.* Commentator *Chakrapani,*and *Samhitas* like *Sharangadhra Samhita* have used the word *Shweta Pradara* for white vaginalDischarges. Though *Kaphadosha* involvementis directly not mentioned but the characteristic clinical feature like *Sneha, Sheeta, Shukla*, *Drava* etc are that of *Kapha* thus *Shweta Pradara* is a *Kaphaja Vyadhi*.Since the pruritis is out of proportion to discharge this can be correlated toCandida vaginitis.
· *Panchavalkala Kashaya* has been taken as standard drug and the combinationof *Guduchi*, *Triphala* and *Danti (Dantyadi) Kashaya* is takenas trial drug as *Dantyadi Kashay*a contains the drugs that are mainly *Tridoshahara,Krumighna, Vishaghna & Vedanasthapana*. Here is an attempt to see andcompare the effect of these formulations in management of *Shweta Pradara*(Candida vaginitis).
· This is a randomized comparativeclinical study. Total 40 patients of *Shweta pradara* who fulfills theInclusion Criteria and having Classical sign and symptoms of *Shweta pradara* willbe selected from the OPD and Medical camps conducted by SDM Trust’s PadmaAyurvedic Hospital and Research Centre, Terdal. These patients are randomlydivided into two groups A and B. Group A will be given *Dantyadi Kashaya yoniprakshalana*and Group B given *Panchavalkala Kashayayoniprakshalana*. Consent will be taken from patient andCase details will be recorded in separate case report form (CRF). Total Study duration will be 30 days and contain9 visits (0th– 7thday, 15th day, 30thday), which includes administration of trial drug for 7days and post medicationfollow up on 15th& 30th day. After study, data willbe collected from case report form (CRF) and statistically analysed by usingappropriate parametric and nonparametrictests and results will be obtained. Onthat basis of results, conclusion will be drawn.
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- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Not Yet Recruiting
- Sex
- Female
- Target Recruitment
- 40
•Patients with Pratyatma Lakshana’s of Shweta Pradara tested positive for presence of Candida albicans through Wet Mount Microscopy •Married women •Subjects willing to sign the consent form.
- •Diagnosed case of PCOD, PID, UTI •Patients with Systemic disorders like HTN, DM •K/C/O Congenital abnormalities.
- •K/C/O Thyroid and Parathyroid diseases, Malignancy •Copper T and OCP using women, Pregnant and Lactating women •K/C/O Cervical Erosion, Cervicitis •K/C/O HIV, Hepatitis B, STD’s.
Study & Design
- Study Type
- Interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method Effect of trial drug in classical symptoms of Shweta Pradara w.s.r to Candida Vaginitis i.e., 15th day, 30th day 2.Yonikandu(Itching). 15th day, 30th day 1.Srava(whiteDischarge). 15th day, 30th day 3. Daurgandhya(FoulSmell). 15th day, 30th day 4.Kati shoola(Backache). 15th day, 30th day 5.Yoni vedana 15th day, 30th day
- Secondary Outcome Measures
Name Time Method Safety of trial drug, adverse reaction & aggravation of symptoms of Shweta Pradara w.s.r Candida vaginitis 1st to 7th day
Trial Locations
- Locations (1)
Padma Ayurvedic Hospital And Research Centre
🇮🇳Bagalkot, KARNATAKA, India
Padma Ayurvedic Hospital And Research Centre🇮🇳Bagalkot, KARNATAKA, IndiaDr Nikita M MagennavarPrincipal investigator886191577013.nikitam@gmail.com