Impact of Short-term Fructose-enriched Diet on Serum Metabolome by Normal- and Over-weighed Women.
- Conditions
- Non-Alcoholic Fatty Liver DiseaseObesity
- Interventions
- Other: Diet
- Registration Number
- NCT03444233
- Lead Sponsor
- University of Hohenheim
- Brief Summary
The purpose of this study is to investigate how a high-fructose diet, either by high fructose intake from complex, natural foods or by fortifying the diet with corn syrup, affects the metabolism. Furthermore, it will be investigate if there are differences between obese and normal weight participants.
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- COMPLETED
- Sex
- Female
- Target Recruitment
- 12
- Healthy adults, aged between 20 and 30 years
- normal weighted (BMI ≤ 25 kg/m2) and obese (BMI 35-50 kg/m2)
- written informed consent
At initial medical examination an anamnesis, physical examination, blood sample collection (10 ml) was performed to check for eligibility. Furthermore, a hydrogen breath test was performed to detect potential fructose intolerance
- smoking,
- fructose intolerance/ -malabsorption,
- pregnancy
- chronic gastrointestinal diseases (e.g. chronic inflammatory bowel disease, irritable bowel syndrome, celiac disease etc.),
- operation on the gastrointestinal tract (exclusively appendectomy)
- anemia,
- hepatic or renal disease
- diabetes mellitus
- consuming illnesses (e.g. cancer, acquired immunodeficiency syndrome (AIDS)) - drug intake affecting lipid or glucose metabolism (cholesterol- or glucose reducing or antihypertensive drugs, steroids, L-Thyroxin, antidepressants, weight reducing drugs).
Study & Design
- Study Type
- INTERVENTIONAL
- Study Design
- CROSSOVER
- Arm && Interventions
Group Intervention Description low f2 diet Diet low fructose diet week 3 HFCS rich diet Diet HFCS rich diet week 4 low f1 diet Diet low fructose diet week 1 fruit rich diet Diet fruit rich diet week 2
- Primary Outcome Measures
Name Time Method metabolite concentration Participants will be followed for the time of four weeks. The primary endpoint is the change of metabolite concentration after low fructose diet week 1, fruit rich diet, low fructose diet week 3 and HFCS rich diet.
- Secondary Outcome Measures
Name Time Method fatty liver index Participants will be followed for the time of four weeks. Change in fatty liver index after low fructose diet week 1, fruit rich diet, low fructose diet week 3 and HFCS rich diet.
Non-alcoholic fatty liver disease (NAFLD) Participants will be followed for the time of four weeks. Change in the classification of non-alcoholic fatty liver disease (NAFLD) based on ultrasound after low fructose diet week 1, fruit rich diet, low fructose diet week 3 and HFCS rich diet.
Body weight Participants will be followed for the time of four weeks. Change from baseline in body weight after low fructose diet week 1, fruit rich diet, low fructose diet week 3 and HFCS rich diet.
Blood pressure (systolic and diastolic) Participants will be followed for the time of four weeks. Change in blood pressure (systolic and diastolic) after low fructose diet week 1, fruit rich diet, low fructose diet week 3 and HFCS rich diet.
GGT Participants will be followed for the time of four weeks. Change in GGT after low fructose diet week 1, fruit rich diet, low fructose diet week 3 and HFCS rich diet.
GOT Participants will be followed for the time of four weeks. Change in GOT after low fructose diet week 1, fruit rich diet, low fructose diet week 3 and HFCS rich diet.
GPT Participants will be followed for the time of four weeks. Change in GPT after low fructose diet week 1, fruit rich diet, low fructose diet week 3 and HFCS rich diet.
AP Participants will be followed for the time of four weeks. Change in AP after low fructose diet week 1, fruit rich diet, low fructose diet week 3 and HFCS rich diet.
Triglycerides Participants will be followed for the time of four weeks. Change in triglycerides after low fructose diet week 1, fruit rich diet, low fructose diet week 3 and HFCS rich diet.
HDL Participants will be followed for the time of four weeks. Change in HDL after low fructose diet week 1, fruit rich diet, low fructose diet week 3 and HFCS rich diet.
LDL Participants will be followed for the time of four weeks. Change in LDL after low fructose diet week 1, fruit rich diet, low fructose diet week 3 and HFCS rich diet.
Fasting glucose Participants will be followed for the time of four weeks. Change in fasting glucose after low fructose diet week 1, fruit rich diet, low fructose diet week 3 and HFCS rich diet.
BSR Participants will be followed for the time of four weeks. Change in BSR after low fructose diet week 1, fruit rich diet, low fructose diet week 3 and HFCS rich diet.
Kreatinine Participants will be followed for the time of four weeks. Change in Kreatinine after low fructose diet week 1, fruit rich diet, low fructose diet week 3 and HFCS rich diet.
Uric acid Participants will be followed for the time of four weeks. Change in uric acid after low fructose diet week 1, fruit rich diet, low fructose diet week 3 and HFCS rich diet.
Urea Participants will be followed for the time of four weeks. Change in urea after low fructose diet week 1, fruit rich diet, low fructose diet week 3 and HFCS rich diet.
Cholesterol Participants will be followed for the time of four weeks. Change in cholesterol after low fructose diet week 1, fruit rich diet, low fructose diet week 3 and HFCS rich diet.
Ghrelin Participants will be followed for the time of four weeks. Change in ghrelin after low fructose diet week 1, fruit rich diet, low fructose diet week 3 and HFCS rich diet.
Leptin Participants will be followed for the time of four weeks. Change in leptin after low fructose diet week 1, fruit rich diet, low fructose diet week 3 and HFCS rich diet.