Analysis of Biomarkers From Patients With Chorioretinal Diseases

Recruiting

• Conditions: Diabetic Retinopathy; Macular Degeneration
• Interventions: Drug: Chorioretinal diseases

• Registration Number: NCT02026843
• Lead Sponsor: Kyungpook National University Hospital

Brief Summary

This study was conducted to investigate the levels of ocular biomarkers from the patients with chorioretinal diseases including diabetic retinopathy, retinal vascular diseases, age-related macular degeneration (dry and wet), and retinal degeneration.

Detailed Description

This prospective, case-control study included 50 patients(50eyes) with chorioretinal diseases including diabetic retinopathy, retinal vascular diseases, age-related macular degeneration (dry and wet), and retinal degeneration. and 50 patient with nondiabetic retinopathy or cataract. Ocular fluids and blood samples were taken before injection of anti-vascular endothelial growth factor agent or pars plana vitrectomy for other retinal disease. Ocular biomarkers were analyzed.

Study Timeline

• Study Start: 2012-04
• Study First Submitted: 2013-12-29
• Study First Submitted QC: 2013-12-31
• Study First Posted: 2014-01-03
• Status Verified: 2025-03
• Last Update Submitted: 2025-03-03
• Last Update Posted: 2025-03-06
• Primary Completion: 2028-02
• Study Completion: 2031-04

Recruitment & Eligibility

• Status: RECRUITING
• Sex: All
• Target Recruitment: 100

Inclusion Criteria

• age over 20 years
• patients requiring ophthalmologic treatments for different degrees of decreasing of visual acuity.
• patients with chorioretinal diseases including diabetic retinopathy, retinal vascular diseases, age-related macular degeneration (dry and wet), and retinal degeneration.
• control patients asking cataract surgery or vitrectomy for posterior segment nonproliferative disorders.

Exclusion Criteria

• under the age of 20 years
• patients that received any anti-vascular endothelial growth factor agent for proliferative disease before taking sample of aqueous humor
• patients that did not signed the informed consent of the trial
• patients with intraocular inflammations or infections that requiring any pharmaceutical agent
• patients with recent ocular trauma

Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Arm && Interventions

Group	Intervention	Description
Chorioretinal diseases	Chorioretinal diseases	chorioretinal diseases including diabetic retinopathy, retinal vascular diseases, age-related macular degeneration (dry and wet), and retinal degeneration.

Primary Outcome Measures

Name	Time	Method
Biomarkers in ocular fluids	one month	To establish if certain type of chorioretinal diseases group are associated to different concentrations of gene or protein concentration.

Trial Locations

Locations (1)

Dong Ho Park; 🇰🇷 Daegu, Kyungsangpookdo, Korea, Republic of