Assessment of the Effects of Aggressive Atorvastatin Therapy on Myocardial Deformation Characteristics, Vascular Rigidity, 24 Hour ECG Monitoring Parameters and Quality of Life in Patients With STEMI
试验速览
- 阶段
- 4 期
- 状态
- 已完成
- 入组人数
- 200
- 试验地点
- 1
- 主要终点
- Cardiovascular events
研究概览
简要总结
The primary goal
• To assess the effect of atorvastatin in patients treated since the first 24-96 hours of the disease on the parameters of global and regional myocardial deformation in the infarcted area and the structural and functional properties of arteries at day 7, at 12, 24, 36 and 48 weeks of treatment;
The secondary goals. To evaluate the effect of treatment:
- on the parameters of the global and regional myocardial deformation in the intact area on day 7, on 12, 24, 36 and 48 weeks of treatment;
- on the parameters of the global and regional myocardial deformation depending on the degree of coronary blood flow restoration by thrombolysis in myocardial infarction (TIMI)
- on systolic and diastolic left ventricular function in the presence of initial impairments, or absence of the negative dynamics of these parameters in case of normal baseline values;
- on the clinical diagnostic criteria for the development or progression of heart failure;
- the dynamics of the duration and extent of myocardial ischemia according to the daily ECG monitoring on day 7, at 12, 24, 36 and 48 weeks of treatment;
- the appearance of new prognostically significant cardiac arrhythmias
- on the pulse wave velocity
- the thickness of the intima-media complex (IMT); 200 patients are planned to be include in a randomized, single-center, open, prospective, controlled clinical trial, the enrollment will be held at the Department of "Therapy" of Medical Institute of Penza State University.
Definition of the study group:
The patients with STEMI (myocardial infarction with ST-segment elevation) will be included in the study
- Group 1 STEMI - 100 patients receiving atorvastatin 80 mg / day for 48 weeks;
- Group 2 STEMI - 100 patients receiving atorvastatin 20 mg / day for 48 weeks Planned number of patients: Pre-Screening - 300 subjects; screening and randomization - 200 subjects.
Patients will be randomized by random number generation to include in the group 1 or 2. All included patients will be on the standard basis therapy of the coronary artery disease, according to the national recommendation.
详细描述
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Hypotheses:
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Atorvastatin therapy directly results in improved deformation characteristics of hibernating myocardium due to its pleiotropic effects on endothelial dysfunction and atherosclerotic plaque stability, as well as stimulation of angiogenesis in ischemic zones of myocardium.
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Long-term atorvastatin therapy improves the morphofunctional properties of large arteries and decreases the severity of endothelial dysfunction in patients with a history of myocardial infarction.
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Atorvastatin causes an anti-ischemic effect, if used for a long time. 2.1. Primary objective To evaluate the effect of atorvastatin, when started between 24 and 96 hours after disease onset, on the parameters of global and regional myocardial deformation in the zone of infarction, as well as morphofunctional properties of arteries, on Day 7 and Weeks 12, 24, 36 and 48 of the treatment; 2.2. Secondary objectives. To evaluate:
- the effect of treatment on the parameters of global and regional myocardial deformation in the zone of intact myocardium on Day 7 and Weeks 12, 24, 36 and 48 of the treatment;
- the effect of treatment on the parameters of global and regional myocardial deformation depending on TIMI blood flow grade;
- the effect of treatment on systolic and diastolic function of the left ventricle in patients with impaired left ventricular function at baseline, as well as the ability of this treatment to prevent deterioration of left ventricular function in patients with normal left ventricular function at baseline;
- the effect of treatment on heart failure development and progression as assessed using the corresponding clinical diagnostic criteria;
- the effect of treatment on duration and time course of myocardial ischemia using 24 hour ECG monitoring on Day 7 and Weeks 12, 24, 36 and 48 of treatment;
- the effect of treatment on the appearance of new prognostically significant disorders of cardiac rhythm;
- the effect of treatment on pulse wave velocity and cardio-ankle vascular index (CAVI);
- the effect of treatment on intima-media thickness (IMT);
- the effect of treatment on the results of automated quantitative vascular elasticity measurements, pulse wave and pulse pressure;
- the effect of treatment on endothelial function using the reactive hyperemia test;
- the effect of treatment on the time course of blood chemistry parameters (i.e., total cholesterol, HDL, LDL, triglycerides, creatinine, C-reactive protein (CRP), alanine transaminase (ALT), aspartate transaminase (AST) and creatinkinase (CK);
- the safety of treatment;
- the effect of treatment on patient's well-being and quality of life;
- patient compliance with the therapy. 2.3. Scientific novelty of the study It is planned to study, for the first time, the effect of long-term aggressive statin therapy on the functional status of myocardium in the zone of ischemia, lesion and necrosis in patients with STEMI using the two-dimensional strain procedure.
It is planned, for the first time, to comprehensively study the effect of aggressive statin therapy on the status of vasculature, with measuring multiple parameters characterizing the morphofunctional status of elastic and muscular arteries in patients with documented coronary heart disease (CHD).
2.4. Clinical significance of study results. If the proposed hypotheses are confirmed after the primary endpoints described in Section 3 have been reached, new convincing evidence supporting the use of long-term aggressive treatment with Atorvastatin starting from the early stages of myocardial infarction will be obtained. Obviously, the clinical benefits will include the improved prognosis and decreased risk of repeated vascular events. Favorable effects of this therapy on the morphofunctional status of arterial vasculature will play an important role in the treatment of these patients. Positive results of this study can form the basis for planning and conducting larger studies on pleiotropic effects of Atorvastatin in patients with a history of myocardial infarction.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Parallel
- 主要目的
- Treatment
- 盲法
- None
入排标准
- 年龄范围
- 35 Years 至 65 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Signed Informed Consent Form
- •Patients having physical and mental ability to participate in the study
- •Patients of both sexes aged 35 to 65 years
- •Presence of documented ST-elevation myocardial infarction confirmed by ECG, as well as troponin I and CK-MB levels.
- •Presence of hemodynamically relevant stenosis of one artery (i.e., the infarct-related artery) confirmed by coronary angiography (CAG), with the occlusion of other arteries not exceeding 30%.
排除标准
- •A history of repeat or recurrent myocardial infarction;
- •A history of chronic heart failure (CHF) III-IV by New-York Heart Association (NYHA);
- •Presence of left ventricular hypertrophy confirmed by echocardiography;
- •QRS complex exceeding 1.0;
- •Ejection fraction less than 40%;
- •Presence of hemodynamically relevant stenosis exceeding 30% in several coronary arteries confirmed by CAG;
- •Type 1 diabetes mellitus;
- •Type 2 diabetes mellitus requiring pharmacotherapeutic correction with insulin;
- •Any severe concurrent disease;
- •A history of acute cerebrovascular accident (ACVA) within the 6 month period preceding the study;
- •Active hepatic disease or liver enzyme elevation of unclear etiology more than 3 times higher than the upper limit of normal;
- •Hepatic failure or bilirubin elevation more than 1.5 times higher than the upper limit of normal;
- •Uncontrolled arterial hypertension (AH), with systolic blood pressure (SBP) exceeding 180 mm Hg and diastolic blood pressure (DBP) exceeding 110 mm Hg;
- •A history of heart rhythm and/or cardiac conduction disorder;
- •Inborn and/or acquired heart defects;
- •A history of aortic aneurysm;
- •Current existence of severe anemia (Hb < 100 g/L);
- •Chronic renal disease (creatinine clearance < 30 mL/min);
- •Uncorrected thyroid dysfunction, with hyper- or hypothyroidism;
- •Intolerance of statins;
- •Alcohol abuse and drug use;
- •Participation in other clinical studies within the last two months.
研究组 & 干预措施
Group A
Group A patients will start atorvastatin at a dose of 80 mg/day between 24 and 96 hours after the onset of STEMI
干预措施: Atorvastatin (Drug)
Group K
Group K patients will start atorvastatin at a dose of 20 mg/day between 24 and 96 hours after the onset of STEMI
干预措施: Atorvastatin (Drug)
结局指标
主要结局
Cardiovascular events
时间窗: 2 years
Myocardial infarction, Unstable angina, Cardiac death
次要结局
- Cardiac-ankle vascular index(2 years)
- Global myocardial strain rate in the zone of previous STEMI and in the intact zone after STEMI(2 years)
- Intima-media thickness of carotid artery(2 years)
- Carotid-femoral pulse wave velocity(2 years)
- Global myocardial strain in the zone of previous STEMI and in the intact zone after STEMI(2 years)