The impact of dietary salt intake on arterial wall function and blood pressure in healthy subjects.

Completed

• Conditions: Hypertension; Cardiovascular - Hypertension

• Registration Number: ACTRN12609000292279
• Lead Sponsor: niversity of Otago

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Results First Posted: 1900-01-01
• Study Start: 2009-05-18
• Last Update Posted: 13 January 2020

Recruitment & Eligibility

• Status: Completed
• Sex: All
• Target Recruitment: 25

Inclusion Criteria

Normotensive, blood pressure < 130/85

Exclusion Criteria

smoking, body mass index > 30, history of cardiovascular disease, renal disease (estimated glomerular filtration rate (eGFR) <85 -[age-30]ml/min) diabetes

Study & Design

• Study Type: Interventional
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Arterial wall function measured by pulse wave velocity[Baseline, week 1, week 2 and week 4]

Secondary Outcome Measures

Name	Time	Method
Blood pressure measured by sphygmomanometer[Baseline, week 1, week 2, week4.];Markers of plasma oxidative stress (highly sensitive-C reactive protein (hs-CRP), nitrate and nitrite concentrations, lipid peroxides, lipofuscin-like flurophores) using standard laboratory measurements.[Baseline, week 1, week 2, week 4];Plasma concentrations of Vasoactive hormones (renin, aldosterone, atrial natriuretic peptide (ANP), brain natriuretic peptide (BNP), N terminal C-natriuretic peptide (CNP), insulin, endothelin 1) using standard laboratory measurements[baseline, week 1 week 2, week 4]