Reproducibility and Repeatability of Multifunctional MRI Biomarkers of the Body
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 13
- 试验地点
- 1
- 主要终点
- repeatability coefficient (RC)
研究概览
简要总结
Advanced MRI (Magnetic Resonance Imaging) technique called DCE (Dynamic Contrast Enhanced) and DWI MRI can provide valuable information regarding tumor biology and response to treatment through various parameters. Validating stability of these parameters will further establish robustness and reliability of these promising biomarkers.
研究设计
- 研究类型
- Interventional
- 分配方式
- Na
- 干预模型
- Single Group
- 主要目的
- Diagnostic
- 盲法
- None
入排标准
- 年龄范围
- 18 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Diagnosis of metastatic liver cancer proven by pathology
- •At least one liver tumor should be > 2cm in long diameter
- •Patients with viable tumor proven in the other imaging modalities
排除标准
- •Severe claustrophobia
- •Presence of MRI-incompatible metallic objects or implanted medical devices in body
- •Renal failure, as determined by glomerular filtration rate (GFR) < 30 mL/min/1.73 m2
- •Weight greater than that allowable by the MRI table
- •Chemotherapy within 28 days prior to enrollment
- •Prior external radiation therapy to the liver, prior transarterial chemoembolization
研究组 & 干预措施
DCE and DWI MRI
MRI SCAN 1 and MRI SCAN 2 must be completed no less than 2 calendar days (to ensure 24 hours for clearance of gadolinium) and no greater than 14 days apart, and both must be completed prior to new treatment initiation. The same MRI unit and configuration must be used for MRI SCAN 1 and MRI SCAN 2.
干预措施: DCE MRI (Other)
结局指标
主要结局
repeatability coefficient (RC)
时间窗: one year
Repeatability coefficient of Ktrans, Kep, Ve, IAUGC60, and ADC value of the index tumor will be measured.
次要结局
未报告次要终点
研究者
Kyung Won Kim
Assistance Professor
Asan Medical Center