Reproducibility and Repeatability of Multifunctional MRI Biomarkers of the Body
Not Applicable
Completed
- Conditions
- Metastatic Liver Cancer
- Interventions
- Other: DCE MRI
- Registration Number
- NCT02201797
- Lead Sponsor
- Asan Medical Center
- Brief Summary
Advanced MRI (Magnetic Resonance Imaging) technique called DCE (Dynamic Contrast Enhanced) and DWI MRI can provide valuable information regarding tumor biology and response to treatment through various parameters. Validating stability of these parameters will further establish robustness and reliability of these promising biomarkers.
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- COMPLETED
- Sex
- All
- Target Recruitment
- 13
Inclusion Criteria
- Diagnosis of metastatic liver cancer proven by pathology
- At least one liver tumor should be > 2cm in long diameter
- Patients with viable tumor proven in the other imaging modalities
Exclusion Criteria
- Severe claustrophobia
- Presence of MRI-incompatible metallic objects or implanted medical devices in body
- Renal failure, as determined by glomerular filtration rate (GFR) < 30 mL/min/1.73 m2
- Weight greater than that allowable by the MRI table
- Chemotherapy within 28 days prior to enrollment
- Prior external radiation therapy to the liver, prior transarterial chemoembolization
Study & Design
- Study Type
- INTERVENTIONAL
- Study Design
- SINGLE_GROUP
- Arm && Interventions
Group Intervention Description DCE and DWI MRI DCE MRI MRI SCAN 1 and MRI SCAN 2 must be completed no less than 2 calendar days (to ensure 24 hours for clearance of gadolinium) and no greater than 14 days apart, and both must be completed prior to new treatment initiation. The same MRI unit and configuration must be used for MRI SCAN 1 and MRI SCAN 2.
- Primary Outcome Measures
Name Time Method repeatability coefficient (RC) one year Repeatability coefficient of Ktrans, Kep, Ve, IAUGC60, and ADC value of the index tumor will be measured.
- Secondary Outcome Measures
Name Time Method
Trial Locations
- Locations (1)
Asan Medical Center
🇰🇷Seoul, Korea, Republic of