Compare ABGA changes in laparoscopy surgery in smokers and non-smokers patients

Not yet recruiting

• Conditions: Diseases of the digestive system,

• Registration Number: CTRI/2022/10/046491
• Lead Sponsor: Government of Gujarat

Brief Summary

Laparoscopic surgery is minimally invasive, creation of pneumo-peritoneum and postural changes associated with it causes a number of physiological alterations which may have an effect on the anaesthesia management and warrant specific caution. Absorption of carbon dioxide (CO2) used in insufflation can cause hypercapnia and respiratory acidosis. This further activates the sympathetic nervous and also sensitises the myocardium to catecholamines.This along with a decrease in preload and venous return due to increased intraabdominal pressure may cause a gross decrease in cardiac output. Chronic smoking (more than 20 pack-year at least for 10 years) causes a number of pathological changes in the respiratory system .As the lung function is already in a compromised state in chronic smokers, creation of pneumoperitoneum for laparoscopic surgeries in such patients further aggravates and causes an alteration in the acid-base status of the body. The aim of this study is to compare the changes in metabolic and gas exchange status between chronic smokers versus non-smokers in patients posted for laparoscopic abdominal surgery by analyzing blood gas parameters.

Detailed Description

Not available

Study Timeline

• Last Update Posted: 2022-08-10
• Study Start: 2022-10-22

Recruitment & Eligibility

• Status: Not Yet Recruiting
• Sex: All
• Target Recruitment: 100

Inclusion Criteria

• Patients aged 20-60yrs.
• ASA 1 and 2.
• Elective laparoscopic surgeries.

Exclusion Criteria

• Patient refusal.
• ASA 3 and 4.
• Patients with other lung and cardiac pathologies.
• Patients with hypertension, uncontrolled diabetes mellitus, systemic infection,, history of malignancy, history of alcohol or drug abuse.
• Emergency operation.

Study & Design

• Study Type: Observational
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
compare the abga changes between chronic smokers vs non-smokers in laparoscopic abdominal surgery	10 minute prior to premedication,10 minute after gas insufflation intraoperative and 10 minute after extubation postoperative period

Secondary Outcome Measures

Name	Time	Method
To take proper precautions to avoid complications due to gas insufflation in laparoscopic surgery.	Intraoperative period and postoperative period up to 12hours.

Trial Locations

Locations (1)

Surgical operation theater; 🇮🇳 Ahmadabad, GUJARAT, India

Surgical operation theater

🇮🇳Ahmadabad, GUJARAT, India

Dr Hirenkumar Patel

Principal investigator

7778910794

hirenpatelradhe8@gmail.com