Anti-inflammatory effect of an herbal mouthwash in periodontal patients

Not Applicable

Active, not recruiting

• Conditions: periodontal disease; periodontal inflammation; Alternative and Complementary Medicine - Herbal remedies; Oral and Gastrointestinal - Other diseases of the mouth, teeth, oesophagus, digestive system including liver and colon

• Registration Number: ACTRN12618001192279
• Lead Sponsor: Istitutional funds from Prof. Putignano and Prof Orsini

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Results First Posted: 1900-01-01
• Study Start: 2018-07-17
• Last Update Posted: 15 July 2019

Recruitment & Eligibility

• Status: Active, not recruiting
• Sex: All
• Target Recruitment: 40

Inclusion Criteria

Systemically healthy, minimum 20 teeth, smoker and no smoker, diagnosis of severe or moderate periodontitis

Exclusion Criteria

Use of antibiotics and anti-inflammatory drugs in previous 6 months, presence of orthodontic appliance, pregnant or lactating females, allergy to the mouthwash ingredients

Study & Design

• Study Type: Interventional
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Differences in mean reduction of inflammation index.<br>Inflammation was measured by recording the bleeding index FMBS (Full Mouth Bleeding Score) on 6 dental surfaces of all teeth, using periodontal probes, according to the criteria of Ainamo and Bay (1975).[Baseline and 3 months post-intervention commencement ];Mouthwash safety was assessed using a questionnaire (specifically designed for this study) in which patients reported any adverse events, including redness of oral mucosa, mouth burning, desquamation, oral dryness, hard tissues brown spots, alteration of taste.<br>[Baseline and 3 months post-intervention commencement ]

Secondary Outcome Measures

Name	Time	Method
Difference in mean change of plaque accumulation index.<br>This was assessed using plaque index FMPS (Full Mouth Plaque Score), using plaque detectors, according to the criteria of O’Leary (1967).[Baseline and 3 months post-intervention commencement];Difference in mean change of probing depth level was assessed using periodontal probes.[Baseline and 3 months post-intervention commencement];Difference in mean change of clinical attachment level, using periodontal probes.[Baseline and 3 months post-intervention commencement]