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临床试验/NCT06767280
NCT06767280招募中不适用

Tensiomyography Evaluation of Gastrocnemius Muscles in Individuals with Chronic Lumbar Radiculopathy

Cairo University1 个研究点 分布在 1 个国家目标入组 38 人开始时间: 2024年11月1日最近更新:
适应症

试验速览

阶段
不适用
状态
招募中
入组人数
38
试验地点
1
主要终点
Comparison of Muscle Contraction Time (Tc) Between Right and Left Gastrocnemius Muscles in Patients with Chronic Lumbar Radiculopathy

研究概览

简要总结

This cross-sectional study aims to evaluate the neuromuscular characteristics of the gastrocnemius muscles in individuals with chronic lumbar radiculopathy using tensiomyography (TMG). By analyzing parameters such as muscle contraction time, displacement, and relaxation time, the study seeks to understand potential alterations in muscle properties that may contribute to functional limitations in this patient population. Findings from this research may provide valuable insights into the role of gastrocnemius muscles in neuromuscular dysfunction and inform tailored rehabilitation strategies.

详细描述

Lumbar radiculopathy is a condition characterized by the compression or irritation of one or more nerve roots in the lumbar spine, often resulting in pain, weakness, numbness, or difficulty controlling specific muscles. The primary causes of lumbar radiculopathy include herniated discs, spinal stenosis, and degenerative disc disease. These conditions lead to nerve root compression, resulting in radiating pain down the leg, commonly referred to as sciatica.

The impact of lumbar radiculopathy extends beyond pain, affecting muscle function and neuromuscular control. The involvement of nerve roots such as L4, L5, and S1 can particularly affect the muscles in the lower extremities, including the plantar flexor muscles, which are crucial for movements like walking, running, and maintaining balance. These muscles, namely the gastrocnemius and soleus, play a pivotal role in plantar flexion, an essential motion for locomotion.

In individuals with lumbar radiculopathy, the neural input to these muscles can be compromised, leading to muscle weakness, altered reflexes, and changes in muscle activation patterns. Studies have shown that patients with lumbar radiculopathy often exhibit decreased muscle strength and endurance in the affected lower extremity. These neuromuscular deficits can contribute to impaired gait mechanics and an increased risk of falls, significantly affecting the quality of life.

Tensiomyography (TMG) is a non-invasive diagnostic tool used to assess the contractile properties of skeletal muscles. TMG measures the muscle belly's displacement in response to a standardized electrical stimulus, providing valuable information about muscle function. Key parameters measured by TMG include contraction time (Tc), delay time (Td), sustain time (Ts), relaxation time (Tr) and Displacement (Dm) reflecting the muscle's response speed, duration of contraction, and recovery.

TMG has gained popularity in both clinical and sports settings due to its ability to detect muscle imbalances, monitor rehabilitation progress, and guide training programs. Its non-invasive nature and the detailed information it provides make it an ideal tool for assessing muscle health and function in various populations, including those with neuromuscular disorders.

研究设计

研究类型
Observational
观察模型
Case Crossover
时间视角
Cross Sectional

入排标准

年龄范围
18 Years 至 55 Years(Adult)
性别
All
接受健康志愿者

入选标准

  • Adults aged 18-55 years.
  • Clinical diagnosis of chronic lumbar radiculopathy confirmed by MRI and clinical examination.
  • Presence of symptoms for more than 12 weeks.
  • One limb is affected by the condition, while the other limb is unaffected and will serve as the control.

排除标准

  • ● Acute lumbar radiculopathy (symptoms less than 12 weeks).
  • History of lower limb surgery or severe musculoskeletal disorders affecting the plantar flexor muscles.
  • Neurological disorders other than lumbar radiculopathy (e.g., peripheral neuropathy, multiple sclerosis).
  • Severe comorbid conditions that might interfere with the study (e.g., uncontrolled diabetes, severe cardiovascular disease).
  • Pregnant or breastfeeding women.
  • Participation in another clinical trial within the last 30 days.
  • Use of medications that could affect muscle function (e.g., corticosteroids, muscle relaxants).

结局指标

主要结局

Comparison of Muscle Contraction Time (Tc) Between Right and Left Gastrocnemius Muscles in Patients with Chronic Lumbar Radiculopathy

时间窗: At baseline (single session)" This fits well if you're measuring contraction times of the gastrocnemius muscles in one session.

This outcome measures the difference in muscle contraction time (Tc) between the right and left gastrocnemius muscles in patients diagnosed with chronic lumbar radiculopathy. Muscle contraction time is assessed using tensiomyography (TMG)

次要结局

未报告次要终点

研究者

申办方类型
Other
责任方
Principal Investigator
主要研究者

Ahmed Mostafa Zaki Nassef

Master's Student, Faculty of Physiotherapy, Cairo University

Cairo University

研究点 (1)

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