Gut Microbiota Dysbiosis and Translocation Within Patients Suffering From Diseases Associated With Increased Intestinal Barrier Permeability : IBD and Parkinson
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 发起方
- 入组人数
- 15
- 试验地点
- 2
- 主要终点
- 16S RNA sequencing in stool sample
研究概览
简要总结
Inflammatory bowel diseases (IBD) and Parkinson disease (PD) are complex and multifactorial pathologies. Gut microbiota seems to play an active role. Indeed the digestive microbiota of patients with IBD or PD exhibits different compositions compared with asymptomatic subjects.
Bacterial translocation from gut to blood has been reported.
详细描述
The investigators designed a case-control study to investigate the digestive microbiota and bacterial translocation during IBD and PD. The investigators want to evaluate gut microbiota bacteria involved in dysbiosis and bacterial translocation during IBD and PD. The investigators want to identify bacterial populations that can serve as biomarkers for clinical practice.
研究设计
- 研究类型
- Interventional
- 分配方式
- Non Randomized
- 干预模型
- Parallel
- 主要目的
- Screening
- 盲法
- None
入排标准
- 年龄范围
- 18 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •PD patients : age < or = 60 years
- •asymptomatic subjects : no chronic disease
- •asymptomatic subjects : no treatment
排除标准
- •severe anemia (Hb<7g/L)
- •people who don't read french
- •pregnant women
- •people treated by antibiotic, probiotic or prebiotic during the 2 month before inclusion
- •people with any diagnosed or treated pathology
结局指标
主要结局
16S RNA sequencing in stool sample
时间窗: 2 years
16S RNA sequencing to identify species constituting the microbiota in the stool
16S RNA sequencing in blood sample
时间窗: 2 years
16S RNA sequencing to identify species constituting the microbiota in the blood
Stool quantification of key bacteria associated with intestinal barrier permeability.
时间窗: 2 years
To determine stool rates of Faecalibacterium prausnitzii, Akkermansia muciniphila, Bacteroides fragilis, Clostridium difficile, Mycobacterium avium paratuberculosis and Escherischia coli by qPCR
Blood quantification of key bacteria associated with intestinal barrier permeability.
时间窗: 2 years
To determine blood rates of Faecalibacterium prausnitzii, Akkermansia muciniphila, Bacteroides fragilis, Clostridium difficile, Mycobacterium avium paratuberculosis and Escherischia coli by qPCR
次要结局
未报告次要终点