NCT06863441尚未招募不适用
The Value of PET Imaging Targeting Granzyme B in Predicting Efficacy and Prognosis in T-NK Cell Lymphoma
试验速览
- 阶段
- 不适用
- 状态
- 尚未招募
- 入组人数
- 50
- 试验地点
- 1
- 主要终点
- Standardized uptake value (SUV)
研究概览
简要总结
The study on the value of PET imaging targeting granzyme B in predicting the efficacy and prognosis of T-NK cell lymphoma.
详细描述
The investigators will number all participants, create a medical record file, and record their basic information (gender, age) as well as contact information and medical history information. All participants will undergo 68Ga-grazytracer PET at baseline and after one course of immunotherapy.
研究设计
- 研究类型
- Observational
- 观察模型
- Other
- 时间视角
- Prospective
入排标准
- 年龄范围
- 18 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Age > 18 years, regardless of gender.
- •Histopathologically confirmed diagnosis of T-NK cell lymphoma.
- •Newly diagnosed and untreated patients or refractory/relapsed patients preparing to undergo immunotherapy.
- •Availability of complete clinicopathological and follow-up data.
- •Signed and dated informed consent form.
排除标准
- •Patients who have previously received anti-tumor therapy.
- •Patients with a history of other malignancies.
- •Incomplete clinical information or imaging data.
- •Concurrent other malignant tumors.
- •Patients with severe medical conditions deemed unsuitable for participation in this clinical study by the investigator, such as severe cardiopulmonary insufficiency or severe hepatic and renal dysfunction.
- •Poor compliance.
结局指标
主要结局
Standardized uptake value (SUV)
时间窗: Baseline and 7-10 days after treatment
SUV of 68Ga-grazytracer uptake on PET/CT images for tumor lesions
次要结局
- Progress free suivival(3 years)
- Overall survival(3 years)
研究者
研究点 (1)
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