ACTRN12609000524291尚未招募4 期
Do subjects with symptomatic knee osteoarthritis demonstrate more widespread mechanical and cold hyperalgesia compared with matched controls, and can this hyperalgesia be better modified by a 2-week course of Arcoxia than placebo?
Curtin University of technology0 个研究点目标入组 80 人开始时间: 2009年7月1日最近更新:
适应症
试验速览
- 阶段
- 4 期
- 状态
- 尚未招募
- 发起方
- 入组人数
- 80
研究概览
简要总结
暂无简介。
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomised controlled trial
- 主要目的
- Treatment
- 盲法
- Blinded (masking used)
入排标准
- 年龄范围
- 50 Years 至 o limit（—）
- 性别
- All
入选标准
- •i) unilateral diagnosis of Knee Osteoarthritis (OA) >6 months
- •ii) knee pain >4/10 on WOMAC pain subscale
- •iii) if pain in contralateral knee, no greater than mild
- •iv) no other significant joint involvement
- •v) American Rheumatology Association (ARA) functional Class I, II or III
- •vi) no athroscopy or injections into index knee in last 6 months.
排除标准
- •i) history of systemic inflammatory or chronic pain disorders (especially fibromyalgia)
- •ii) neurological deficit
- •iii) recent (<6 months) lower limb surgery
- •iv) allergic reaction to Non-steroidal anti-inflammatory drugs (NSAIDs) or aspirin
- •v) skin allergies, dermatitis
- •vi) contraindications to Cox-2 inhibitors: congestive heart failure (New York Heart Association Classifications II-IV); unstable hypertension; ischaemic heart disease, peripheral artery disease, cerebrovascular disease including coronary artery bypass graft or angioplasty within 1 year; severe hepatic dysfunction; active gastro-intestinal tract bleeding or peptic ulceration; reduced creatinine clearance <30mL/min
- •vii) current use of high dose (>325mg daily) aspirin
研究者
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