ACTRN12609000524291
Not Yet Recruiting
Phase 4
Do subjects with symptomatic knee osteoarthritis demonstrate more widespread mechanical and cold hyperalgesia compared with matched controls, and can this hyperalgesia be better modified by a 2-week course of Arcoxia than placebo?
Curtin University of technology0 sites80 target enrollmentJuly 1, 2009
Overview
- Phase
- Phase 4
- Intervention
- Not specified
- Conditions
- osteoarthritis
- Sponsor
- Curtin University of technology
- Enrollment
- 80
- Status
- Not Yet Recruiting
- Last Updated
- 6 years ago
Overview
Brief Summary
No summary available.
Investigators
Eligibility Criteria
Inclusion Criteria
- •i) unilateral diagnosis of Knee Osteoarthritis (OA) \>6 months
- •ii) knee pain \>4/10 on WOMAC pain subscale
- •iii) if pain in contralateral knee, no greater than mild
- •iv) no other significant joint involvement
- •v) American Rheumatology Association (ARA) functional Class I, II or III
- •vi) no athroscopy or injections into index knee in last 6 months.
Exclusion Criteria
- •i) history of systemic inflammatory or chronic pain disorders (especially fibromyalgia)
- •ii) neurological deficit
- •iii) recent (\<6 months) lower limb surgery
- •iv) allergic reaction to Non\-steroidal anti\-inflammatory drugs (NSAIDs) or aspirin
- •v) skin allergies, dermatitis
- •vi) contraindications to Cox\-2 inhibitors: congestive heart failure (New York Heart Association Classifications II\-IV); unstable hypertension; ischaemic heart disease, peripheral artery disease, cerebrovascular disease including coronary artery bypass graft or angioplasty within 1 year; severe hepatic dysfunction; active gastro\-intestinal tract bleeding or peptic ulceration; reduced creatinine clearance \<30mL/min
- •vii) current use of high dose (\>325mg daily) aspirin
Outcomes
Primary Outcomes
Not specified
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