Household Air Pollution and Pregnancy Outcome
Trial Snapshot
- Phase
- Not Applicable
- Status
- Completed
- Sponsor
- University of Chicago
- Enrollment
- 307
- Locations
- 1
- Primary Endpoint
- Adverse Pregnancy Outcomes
Study Overview
Brief Summary
Exposure to Household air pollution (HAP) from burning biomass fuels is responsible for an estimated 2.5 million premature deaths and 3.7% of the loss of disability-adjusted life years (DALY) every year in developing countries.52-54 Of all environmental risks, such as unsafe water, poor sanitation, climate change and lead exposure, HAP accounts for the most mortality and DALY.55 Despite the magnitude of the problems associated with HAP, research on its health effects has been hindered by lack of accurate data on exposure and health outcomes. There are few studies available that report HAP exposures and development of adverse pregnancy outcomes from households using biomass fuels.
Study Design
- Study Type
- Interventional
- Allocation
- Randomized
- Intervention Model
- Parallel
- Primary Purpose
- Prevention
- Masking
- None
Eligibility Criteria
- Ages
- — to 35 Years (Child, Adult)
- Sex
- Female
- Accepts Healthy Volunteers
- No
Inclusion Criteria
- •Pregnant women who present to the hospital
- •Who cook exclusively with either kerosene or firewood
- •Before the fourteenth week of pregnancy as determined by ultrasound imaging
Exclusion Criteria
- •Smoking women or women with smoking family members
- •Women with a high-risk pregnancy defined as:
- •Women with uncontrolled hypertension
- •Women greater than 35 years old carrying their first child
- •Women having triplets or more
- •Women who have had a previous C-section
- •Women carrying babies with fetal abnormalities or as determined by the obstetrician.
Outcomes
Primary Outcomes
Adverse Pregnancy Outcomes
Time Frame: At birth
(first trimester miscarriages, intrauterine growth retardation, low birth weight (300gm less weight in controls relative to intervention group, premature deliveries (deliveries before 37 weeks of pregnancy) and still births.
Secondary Outcomes
- Reduction in personal exposure to PM2.5, CO and PAH(At birth)