L-Tyrosine Supplementation in Patients With Fibromyalgia
试验速览
- 阶段
- 不适用
- 状态
- 终止
- 入组人数
- 15
- 试验地点
- 1
- 主要终点
- Pain Score
研究概览
简要总结
Patients in the study, who have a diagnosis of fibromyalgia, will be randomly assigned to take the amino acid L-tyrosine or placebo (blank pill) for 3 weeks. They will fill out questionnaires about their symptoms and see if they have any improvement. The investigators hypothesis is that taking tyrosine will help alleviate the symptoms of fibromyalgia.
详细描述
Fibromyalgia is a chronic pain syndrome with few treatment options available. The amino-acid L-tyrosine is the precursor for norepinephrine in the central nervous system (CNS). Norepinephrine in the CNS has important roles in pain and mood modulation and descending inhibition of pain pathways. By giving the precursor L-tyrosine in high doses we believe that we can increase levels of norepinephrine in the CNS. To study this question we designed a randomized blinded pilot study of 30 patients. Patients are randomly assigned to one of 3 groups (placebo, tyrosine 1000mg/day, and tyrosine 2000mg/day.) for 3 weeks. Patients then complete the Brief Pain Inventory (BPI) daily and the Fibromyalgia impact questionnaire (FIQ) on day 1 and day 21. Patients also complete a drug diary. They are monitored weekly for progress during the study.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Parallel
- 主要目的
- Treatment
- 盲法
- Double (Participant, Investigator)
入排标准
- 年龄范围
- 18 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Diagnosis of fibromyalgia
- •Pain greater than 4/10
- •Age greater than 18
排除标准
- •Age less than 18
研究组 & 干预措施
Tyrosine 1000 mg / day
Patients receive 1000 mg tyrosine per day.
干预措施: Tyrosine (Drug)
Tyrosine 2000 mg / day
Patients receive 2000 mg tyrosine per day.
干预措施: Tyrosine (Drug)
Placebo
Patients receive placebo daily.
干预措施: Placebo (Drug)
结局指标
主要结局
Pain Score
时间窗: daily for 21 days
FIQ Score
时间窗: Day 21
次要结局
未报告次要终点