Glycemic Load & Resistance Training on Endothelial Function & Insulin Sensitivity

Not Applicable

Completed

• Conditions: 160 Participants Aged 18-35 Years and Obese (BMI ≥30) Open to Men and Women of All Ethnicity
• Interventions: Other: Glycemic Load; Other: Resistance Training

• Registration Number: NCT01755962
• Lead Sponsor: University of California, Los Angeles

Brief Summary

This project is prompted by the urgent public health need to identify novel strategies to prevent cardiovascular disease (CVD) and type 2 diabetes (T2D). The higher prevalence of CVD, T2D, and metabolic syndrome in obese individuals is a major healthcare concern. Therefore, finding optimal intervention strategies to combat these growing epidemics is imperative.

Detailed Description

At present, the extent to which dietary components can modify endothelial function, monocyte inflammation and glycemic variations is not well defined, although different carbohydrates are known to vary in their abilities to induce plasma glucose and insulin responses. Epidemiologic work suggests that high dietary glycemic load (GL) is associated with increased concentrations of inflammatory cytokines, endothelial dysfunction markers, and increased risk of T2D and coronary heart disease (CHD). We are examining using randomized control trials low vs. high-GL diet to determine if low-GL diets induce improvements in endothelial function or monocyte inflammation. Furthermore, resistance training is an alternate form of exercise from conventional aerobic training. Resistance Training has the potential to improve endothelial function or monocyte phenotype, but there is very little data in this area. We hypothesize that resistance training may augment the beneficial effects of a low-GL diet in improving metabolic health.

Basic Information
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Recruitment & Eligibility
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Study & Design
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Trial Locations

Study Timeline

• Study Start: 2012-04
• Study First Submitted: 2012-10-11
• Study First Submitted QC: 2012-12-19
• Study First Posted: 2012-12-24
• Primary Completion: 2017-12-14
• Study Completion: 2017-12-14
• Status Verified: 2020-11
• Last Update Submitted: 2020-11-12
• Last Update Posted: 2020-11-16

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 88

Inclusion Criteria

• 18-35 with BMI≥30 and/or your waist circumference ≥40 inches for males or ≥35 inches for females
• In good health as determined by the screening visit and review of medical history

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Exclusion Criteria

• Have a known heart arrhythmia and/or abnormalities found in electrocardiogram (ECG) reading or use of medications that influence CV function
• Have been in a weight loss or exercise program in the 6 months prior to participation
• Use tobacco products
• Have a syndrome or are prescribed medications that may influence body composition, insulin action, or CVD (e.g. PCOS, prednisone, methylphenidate, etc.)
• Have intolerance to lactose or gluten
• Pregnant

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Study & Design

• Study Type: INTERVENTIONAL
• Study Design: FACTORIAL

Arm && Interventions

Group	Intervention	Description
High Glycemic Load + Resistance Training	Resistance Training	12-week control diet + resistance training (1 hour, 3 times per week)
Low Glycemic Load + Resistance Training	Glycemic Load	12-week intervention diet + resistance training (1 hour, 3 times per week)
Low Glycemic Load + Resistance Training	Resistance Training	12-week intervention diet + resistance training (1 hour, 3 times per week)
High Glycemic Load	Glycemic Load	12-week control diet
High Glycemic Load + Resistance Training	Glycemic Load	12-week control diet + resistance training (1 hour, 3 times per week)
Low Glycemic Load	Glycemic Load	12-week intervention diet

Primary Outcome Measures

Name	Time	Method
Endothelial function as determined by brachial artery FMD	12 weeks

Secondary Outcome Measures

Name	Time	Method
monocyte inflammation	12 weeks
Insulin Sensitivity by Oral Glucose Tolerance Test	12 weeks
MAGE via Continuous Glucose Monitoring System	12 weeks

Trial Locations

Locations (1)

University of California, Los Angeles; 🇺🇸 Los Angeles, California, United States