Focal Radiation and chemotherapy avoiding skull and spine for WNT subgroup medulloblastoma
Not Applicable
- Conditions
- Health Condition 1: G938- Other specified disorders of brainHealth Condition 2: null- WNT subgroup Medulloblastoma
- Registration Number
- CTRI/2017/12/010767
- Lead Sponsor
- Tata Memorial Hospital
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Closed to Recruitment of Participants
- Sex
- Not specified
- Target Recruitment
- 0
Inclusion Criteria
Newly diagnosed WNT pathway medulloblastoma
Post surgery residual disease less than 1.5 cm2 on post operative MRI brain.
No evidence of metastatic disease in the brain, spine or cerebral spinal fluid (CSF) assessed by MRI of the brain and spine and a lumbar puncture for CSF cytology.
Exclusion Criteria
Age Less than 3 and more than 16 years.
Molecular subgroup other than WNT pathway.
Post surgery residual disease more than 1.5cm2 on post-operative imaging
Evidence of any metastatic disease in the brain, spine or cerebral spinal fluid (CSF).
Previous history of radiotherapy or chemotherapy prior to study enrollment.
Study & Design
- Study Type
- Interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method Relapse free survivalTimepoint: Relapse free survival
- Secondary Outcome Measures
Name Time Method To evaluate neurocognitive outcomes and endocrine function prospectively using this approach.Timepoint: To evaluate neurocognitive outcomes and endocrine function prospectively using this approach.