Construction of a Clinical Prediction Model for In-Hospital Rebleeding in Patients With Acute Non-Venous Upper Gastrointestinal Bleeding
试验速览
- 阶段
- 不适用
- 状态
- 招募中
- 发起方
- 入组人数
- 1,000
- 试验地点
- 1
- 主要终点
- relbeeding
研究概览
简要总结
ANVUGIB is a serious condition that can cause symptoms like vomiting blood or passing black stools. Although treatments have improved, about 10% to 30% of patients experience rebleeding shortly after their initial treatment, which increases the risk of death.
Currently, doctors use tools like the Glasgow-Blatchford Score, Rockall Score, and AIM65 Score to predict how patients with ANVUGIB might recover. However, these tools are not very effective at identifying patients who are at risk for rebleeding. This study aims to create a new, more accurate prediction model to help doctors identify high-risk patients earlier. The investigators believe that a new predictive model, which combines patient symptoms, lab test results, and imaging findings, will improve the ability to identify patients at high risk of rebleeding compared to existing tools.The goal is to provide doctors with a more reliable tool to guide their decisions, such as when to give preventive treatments or increase monitoring. This could lead to better outcomes and reduce the risk of complications or death.
This study uses patient data collected during routine care to develop and test the new model, ensuring the findings are directly applicable to real-world clinical settings.
研究设计
- 研究类型
- Observational
- 观察模型
- Cohort
- 时间视角
- Retrospective
入排标准
- 年龄范围
- 18 Years 至 —(Adult, Older Adult)
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •age exceeding 18 years,
- •Clinical diagnosis of Acute Non-Variceal Upper Gastrointestinal Bleeding ,
- •patients who underwent endoscopy within 24 hours of admission with confirmation of non-variceal bleeding
排除标准
- •Upper Gastrointestinal Bleeding during hospitalization;
- •transfer from other hospitals;
- •variceal bleeding;
- •lower gastrointestinal bleeding.;
- •bleeding attributed to systemic diseases like disseminated intravascular coagulation (DIC) and hematological disorders;
- •patients with incomplete clinical data or laboratory test results;
- •patients who either requested early discharge or declined gastroscopy.
结局指标
主要结局
relbeeding
时间窗: up to 7 days
Rebleeding was defined as hematemesis, hematochezia, and/or melena within 7 days of the initial bleeding, accompanied by hemodynamic instability or a decrease in hemoglobin of at least 2 g/dl within 24 hours.
次要结局
未报告次要终点
研究者
Junwei Yan
Principal Investigator
Wuhan Central Hospital
