A comparative experimental study to assess the efficacy of administration of individualised homoeopathic medicine in solid globule form and liquid dilution form in treatment of migraine.

Migraine is a common and disabling neurological disorder, often managed with Homoeopathy. Traditionally, medicines are given in solid globule form, but liquid dilution form is also widely used. This study aims to compare the effectiveness of individualized Homoeopathic medicines administered in solid globule versus liquid dilution forms in patients with migraine.

A total of 50 patients (25 in each group) will be enrolled and randomized. Diagnosis will be based on ICHD-3 criteria. The primary outcome will be reduction in disability as measured by the Migraine Disability Assessment (MIDAS) score. Secondary outcomes will include frequency and intensity of attacks, patient compliance, satisfaction, and recurrence rates. The study duration is 12 months, with follow-ups every 15 days.

The trial is expected to provide clinical evidence on whether the dosage form (globules or liquid dilution) influences therapeutic outcomes in migraine.