Evaluation of the clinical and metabolic outcomes of pharmacotherapy based total parental nutrition support in adult patients undergoing bone marrow transplantatio
Phase 2
- Conditions
- Parental nutrition support in bone marrow transplantation.Other medical procedures as the cause of abnormal reaction of the patient, or of later complication, without mention of misadventure at the time of the procedure
- Registration Number
- IRCT201203041030N9
- Lead Sponsor
- Hematology-Oncology & SCT Research Center
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Complete
- Sex
- All
- Target Recruitment
- 60
Inclusion Criteria
1- Age =18 years; 2- <50% oral intake due to nausea, vomiting, diarrhea, anorexia, Severe mocusitis or Graft versus host disease (GVHD) and cannot use of entral feeding; 3- albumin<3. Exclusion criteria: 1- Documented history of respiratory, hepatic, renal and cardiac dysfunction.
Exclusion Criteria
Not provided
Study & Design
- Study Type
- interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method ength of stay (LOS). Timepoint: Participants will be followed for the duration of hospital stay, an expected average of 3 weeks. Method of measurement: Mediacl record.;Incidence of acute GVHD. Timepoint: Three months after intervention. Method of measurement: Physical Examination.;Nutritional status at discharge. Timepoint: Participants will be followed for the duration of hospital stay, an expected average of 3 weeks. Method of measurement: Subjective global assessment (SGA), nutritional risk screening (NRI), anthropometric measurements, nitrogen balance, and laboratory data (such as albumin, prealbumin and total protein).
- Secondary Outcome Measures
Name Time Method Days on antibiotics. Timepoint: Participants will be followed for the duration of hospital stay, an expected average of 3 weeks. Method of measurement: Medical record.;Days of fever. Timepoint: Participants will be followed for the duration of hospital stay, an expected average of 3 weeks. Method of measurement: Medical record.;Liver function tests (LFTs). Timepoint: Participants will be followed for the duration of hospital stay, an expected average of 3 weeks. Method of measurement: Laboratory Examination.;Rate of electrolyte disturbance. Timepoint: Participants will be followed for the duration of hospital stay, an expected average of 3 weeks. Method of measurement: Laboratory Examination.;Rate of PN-related complications. Timepoint: Participants will be followed for the duration of hospital stay, an expected average of 3 weeks. Method of measurement: Medical record.