Effects of food supplementation with vegetable oils containing Medium Chain Triglycerides on the nutritional status and development of inflammation in patients with elephantiasis
- Conditions
- ymphatic FilariasisLymphedemaC01.610.335.508.700.750.361
- Registration Number
- RBR-82rpdv9
- Lead Sponsor
- niversidade Federal de Pernambuco
- Brief Summary
ymphatic filariasis is a neglected tropical disease, which stands out as an important public health problem worldwide, with lymphedema as one of its main clinical manifestations.The use of medium chain triglycerides (MCT) as supplementary treatment can act in the involution of this condition. This study aims to investigate the effect of MCT supplementation on nutritional, metabolic and quality of life parameters in patients with lower limb lymphedema. For this purpose, the participants received nutritional assistance and were submitted to an assessment of their body composition and determination of their biochemical profile. The assessment of quality of life will occur by applying the WHOQOL BREF (WHO) test. As for the experimental groups, patients were randomly divided according to nutritional supplementation into 3 groups: TCM 100% Group, Coconut Oil Group and Soybean Oil Group - Control. For the evaluation of body composition were used: densitometry by double emission X-ray, bioelectrical impedance and summation of skinfolds. A significance level of 5% was adopted for all tests. All analyzes were performed using Stata 14.0 (StataCorp LP, College Station, USA). The use of vegetable oils source of TCM associated with nutritional monitoring promoted a reduction in body mass index, waist circumference, waist-to-height ratio and hip circumference, and an increase in fat-free mass. In addition, extra virgin coconut oil acted in the modulation of adiposity in different evaluation parameters. The modulation exerted on inflammatory markers was due to the elevation of IL-2 and IL-4 levels in patients who received TCM oil. Extra virgin coconut oil was effective in the involution of lymphedema in the patients in this study. In addition, it promoted an improvement in the quality of life in different domains. Nutritional monitoring and supplementation, instituted here, had beneficial effects both in metabolic variables and in the extent of lymphedema, as well as in the perception of quality of life. This integrates the care proposal for patients with lymphedema and favors the individual capacity to exercise citizenship.
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Data analysis completed
- Sex
- Not specified
- Target Recruitment
- Not specified
Patients registered at the National Reference Service for Filariasis (Fiocruz-PE); residents in an endemic area for lymphatic filariasis; of both genders; aged between 18 and 85 years old, who had lymphedema of the lower limbs
Patients with edema or lymphedema due to liver diseases, neoplasms, congenital lymphatic alterations, cardiac and/or vascular insufficiencies, who, after medical screening, have no indication for follow-up at the Serviço de Referência Nacional em Filarioses (Fiocruz Pernambuco); patients who were already undergoing nutritional monitoring outside Fiocruz Pernambuco, or who had neurological and/or psychiatric diseases that could make it difficult to understand dietary guidelines; pregnant and/or lactating patients; patients who reported rejections, intolerances or allergies to the use of medium chain triglyceride oil as well as coconut oil
Study & Design
- Study Type
- Intervention
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method Expected outcome 1: To evaluate the effect of using source oils of medium-chain fatty acids (extra virgin coconut oil and medium-chain triglyceride oil - TCM oil) on the evolution of lymphedema, verified by perimetry of the affected limb, of lower limbs of resident patients in endemic areas for lymphatic filariasis;Outcome found 1: Extra virgin coconut oil was effective in the involution of lymphedema in the study patients. Monitoring the perimetry of the affected limb (over the 70 days of intervention) showed a reduction in measurements that measure the magnitude of lymphedema at different points (foot, leg, knee and thigh). TCM oil did not promote a significant reduction in lymphedema
- Secondary Outcome Measures
Name Time Method