Comparison of effect of Saffron versus memantine in patients with severe Alzheimer's disease
- Conditions
- Alzheimer's disease.
- Registration Number
- IRCT201203051556N39
- Lead Sponsor
- Tehran University of Medical Sciences
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Complete
- Sex
- All
- Target Recruitment
- 50
Inclusion Criteria: A diagnosis of Alzheimer’s disease according to the criteria of National Institute of Neurological and Communicative Disorders and Stroke and Alzheimer’s Disease and Related Disorders Association (NINCDS/ADRDA); Presence of severe dementia: MMSE8-14].
Concomitant diseases such as hypertension, congestive heart failure, non-insulin dependent diabetes mellitus and hypothyroidism; Patients with evidence of other neurodegenerative disorders; Any cardiovascular disease likely to prevent completion of the study; Clinically significant psychiatric diseases; Urinary outflow obstruction; Active peptic ulcer; Any history of epilepsy; Significant drug or alcohol misuse; Drugs with anticholinergic effects or cholinomimetic effects
Study & Design
- Study Type
- interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method Alzheimer's severity. Timepoint: Every month. Method of measurement: SCIRS.
- Secondary Outcome Measures
Name Time Method Severity of Alzheimer. Timepoint: Every Month. Method of measurement: FAST.