PRESEPSIN: Biomarker in the Early Diagnosis of Sepsis
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 发起方
- 入组人数
- 90
- 试验地点
- 2
- 主要终点
- incidence of mortality at 30-days
研究概览
简要总结
Intra-abdominal infections are a common cause of sepsis and frequently occur in intensive care unit (ICU) patient. Various markers such as procalcitonin, presepsin and endotoxin are used to identify patients at risk of sepsis or to guide proper treatment.
No studies compared presepsin to procalcitonin and endotoxin in patients treated with by extracorporeal hemoperfusion with a polymyxin-B-adsorbing cartridge (PMX-HA).
详细描述
Intra-abdominal infections are a common cause of sepsis and frequently occur in intensive care unit (ICU) patient. Various markers such as procalcitonin, presepsin and endotoxin are used to identify patients at risk of sepsis or to guide proper treatment. Particularly, endotoxin can be removed from the blood by extracorporeal hemoperfusion with a polymyxin-B-adsorbing cartridge (PMX-HA).
No studies compared presepsin to procalcitonin and endotoxin in patients treated with PMX-HA. The investigators aim to evaluate the trend and prognostic value of presepsin versus procalcitonin and endotoxin in ICU patients with septic shock from complicated major abdominal surgery, treated with PMX-HA.
研究设计
- 研究类型
- Interventional
- 分配方式
- Na
- 干预模型
- Sequential
- 主要目的
- Diagnostic
- 盲法
- None
入排标准
- 年龄范围
- 18 Years 至 80 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •caucasian patients
- •patients undergoing laparoscopic major abdominal surgery
排除标准
- •pregnancy,
- •organ transplantation,
- •palliative care
- •metastatic cancer
- •head trauma and polytrauma
- •coagulopathies
- •use of anticoagulants
- •neurological disease
- •autoimmune disease
- •thyroid disease.
结局指标
主要结局
incidence of mortality at 30-days
时间窗: up to 30 days
incidence of mortality
次要结局
未报告次要终点
研究者
Cotoia Antonella
Principal Investigator
University of Foggia