PRESEPSIN: Biomarker in the Early Diagnosis of Sepsis
Overview
- Phase
- Not Applicable
- Intervention
- Not specified
- Conditions
- Septic Shock
- Sponsor
- University of Foggia
- Enrollment
- 90
- Locations
- 1
- Primary Endpoint
- incidence of mortality at 30-days
- Status
- Completed
- Last Updated
- 2 years ago
Overview
Brief Summary
Intra-abdominal infections are a common cause of sepsis and frequently occur in intensive care unit (ICU) patient. Various markers such as procalcitonin, presepsin and endotoxin are used to identify patients at risk of sepsis or to guide proper treatment.
No studies compared presepsin to procalcitonin and endotoxin in patients treated with by extracorporeal hemoperfusion with a polymyxin-B-adsorbing cartridge (PMX-HA).
Detailed Description
Intra-abdominal infections are a common cause of sepsis and frequently occur in intensive care unit (ICU) patient. Various markers such as procalcitonin, presepsin and endotoxin are used to identify patients at risk of sepsis or to guide proper treatment. Particularly, endotoxin can be removed from the blood by extracorporeal hemoperfusion with a polymyxin-B-adsorbing cartridge (PMX-HA). No studies compared presepsin to procalcitonin and endotoxin in patients treated with PMX-HA. The investigators aim to evaluate the trend and prognostic value of presepsin versus procalcitonin and endotoxin in ICU patients with septic shock from complicated major abdominal surgery, treated with PMX-HA.
Investigators
Cotoia Antonella
Principal Investigator
University of Foggia
Eligibility Criteria
Inclusion Criteria
- •caucasian patients
- •patients undergoing laparoscopic major abdominal surgery
Exclusion Criteria
- •pregnancy,
- •organ transplantation,
- •palliative care
- •metastatic cancer
- •head trauma and polytrauma
- •coagulopathies
- •use of anticoagulants
- •neurological disease
- •autoimmune disease
- •thyroid disease.
Outcomes
Primary Outcomes
incidence of mortality at 30-days
Time Frame: up to 30 days
incidence of mortality