Comparing Diuretic Strategies in Hospitalized Heart Failure

Phase 4

Withdrawn

• Conditions: Heart Failure
• Interventions: Drug: Loop Diuretics vs. loop + thiazide diuretics

• Registration Number: NCT03999216
• Lead Sponsor: Stanford University

Brief Summary

We will conduct a pragmatic randomized trial comparing whether using a combination of two types of diuretics (loop + thiazide) compared with using a single diuretic (loop only) will result in shorter hospital stays for patients hospitalized with heart failure.

Detailed Description

Not available

Study Timeline

• Study First Submitted: 2019-06-24
• Study First Submitted QC: 2019-06-24
• Study First Posted: 2019-06-26
• Status Verified: 2023-04
• Last Update Submitted: 2023-04-10
• Last Update Posted: 2023-04-12
• Study Start: 2023-07
• Primary Completion: 2024-01
• Study Completion: 2024-06

Recruitment & Eligibility

• Status: WITHDRAWN
• Sex: All
• Target Recruitment: Not specified

Inclusion Criteria

Any adult (age ≥18 years) admitted to the Heart Failure Service at Stanford Health Care with an indication for treatment with a diuretic.

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Exclusion Criteria

1. admission to the intensive care unit or cardiac care units
2. maintenance dialysis on admission
3. any mechanical circulatory support on admission
4. history of heart transplant
5. allergy / intolerance to loop or thiazide diuretics
6. admission serum sodium < 125 meq/L (from EPIC)
7. admission serum potassium < 3.0 meq/L (from EPIC)

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Study & Design

• Study Type: INTERVENTIONAL
• Study Design: PARALLEL

Arm && Interventions

Group	Intervention	Description
Loop only	Loop Diuretics vs. loop + thiazide diuretics	Participants will receive a loop diuretic for up to the first 72 hours of hospitalization. The specific drug, dose and route are left to the treating providers.
Loop + Thiazide	Loop Diuretics vs. loop + thiazide diuretics	Participants will receive a loop+thiazide diuretic for up to the first 72 hours of hospitalization. The specific drugs, doses and routes are left to the treating providers.

Primary Outcome Measures

Name	Time	Method
Hospital length of stay	During hospitalization up to 90 days

Secondary Outcome Measures

Name	Time	Method
Composite of all-cause rehospitalizations, emergency department visits, or death in the 30 days after hospital discharge.	30 days

Trial Locations

Locations (1)

Stanford Health Care; 🇺🇸 Palo Alto, California, United States