Creating a Platform for Point-of-Care Pragmatic Clinical Trials: Comparing Diuretic Strategies in Heart Failure
试验速览
- 阶段
- 4 期
- 状态
- 撤回
- 试验地点
- 1
- 主要终点
- Hospital length of stay
研究概览
简要总结
We will conduct a pragmatic randomized trial comparing whether using a combination of two types of diuretics (loop + thiazide) compared with using a single diuretic (loop only) will result in shorter hospital stays for patients hospitalized with heart failure.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Parallel
- 主要目的
- Treatment
- 盲法
- None
入排标准
- 年龄范围
- 18 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Any adult (age ≥18 years) admitted to the Heart Failure Service at Stanford Health Care with an indication for treatment with a diuretic.
排除标准
- •admission to the intensive care unit or cardiac care units
- •maintenance dialysis on admission
- •any mechanical circulatory support on admission
- •history of heart transplant
- •allergy / intolerance to loop or thiazide diuretics
- •admission serum sodium < 125 meq/L (from EPIC)
- •admission serum potassium < 3.0 meq/L (from EPIC)
研究组 & 干预措施
Loop only
Participants will receive a loop diuretic for up to the first 72 hours of hospitalization. The specific drug, dose and route are left to the treating providers.
干预措施: Loop Diuretics vs. loop + thiazide diuretics (Drug)
Loop + Thiazide
Participants will receive a loop+thiazide diuretic for up to the first 72 hours of hospitalization. The specific drugs, doses and routes are left to the treating providers.
干预措施: Loop Diuretics vs. loop + thiazide diuretics (Drug)
结局指标
主要结局
Hospital length of stay
时间窗: During hospitalization up to 90 days
次要结局
- Composite of all-cause rehospitalizations, emergency department visits, or death in the 30 days after hospital discharge.(30 days)
研究者
Tara I-Hsin Chang
Associate Professor of Medicine (Nephrology)
Stanford University