A Trial of Minocycline for Pain After Carpal Tunnel and Trigger Release
试验速览
- 阶段
- 2 期
- 状态
- 已完成
- 发起方
- 入组人数
- 131
- 试验地点
- 1
- 主要终点
- Time to Pain Resolution
研究概览
简要总结
The investigators are looking at whether peri-operative minocycline will reduce the duration of pain after minor hand surgery: carpal tunnel release and trigger finger release.
The investigators' hypothesis is that minocycline will reduce post-operative pain.
详细描述
This is a double blinded randomized controlled trial. Patients are given 100mg of minocycline 2 hours prior to their procedure and then 100mg two times a day for 5 days. The subjects are then contacted daily to check their level of pain. The investigators' outcome of interest is time to pain resolution.
The investigators will perform a futility analysis to assess if a larger trial would be a reasonable next step after this pilot study.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Parallel
- 主要目的
- Prevention
- 盲法
- Quadruple (Participant, Care Provider, Investigator, Outcomes Assessor)
入排标准
- 年龄范围
- 18 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •Adult, Veteran,
排除标准
- •Kidney failure, Liver failure, thrombocytopenia, ALS, SLE, Frailty, unable to understand survery
研究组 & 干预措施
minocycline
perioperative minocycline for 5 days, starting 2 hours prior to surgery then 100mg BID
干预措施: Minocycline (Drug)
Placebo
PLacebo
干预措施: placebo (Drug)
结局指标
主要结局
Time to Pain Resolution
时间窗: up to 365 days
the time until patient answers no pain at surgical site for three consecutive days
次要结局
未报告次要终点
研究者
Catherine Curtin
Staff Physician
VA Palo Alto Health Care System