Minocycline to Reduce Pain After Carpal Tunnel Release
- Conditions
- Chronic PainPost-operative Pain
- Interventions
- Drug: placebo
- Registration Number
- NCT02051296
- Lead Sponsor
- VA Palo Alto Health Care System
- Brief Summary
The investigators are looking at whether peri-operative minocycline will reduce the duration of pain after minor hand surgery: carpal tunnel release and trigger finger release.
The investigators' hypothesis is that minocycline will reduce post-operative pain.
- Detailed Description
This is a double blinded randomized controlled trial. Patients are given 100mg of minocycline 2 hours prior to their procedure and then 100mg two times a day for 5 days. The subjects are then contacted daily to check their level of pain. The investigators' outcome of interest is time to pain resolution.
The investigators will perform a futility analysis to assess if a larger trial would be a reasonable next step after this pilot study.
Recruitment & Eligibility
- Status
- COMPLETED
- Sex
- All
- Target Recruitment
- 131
- Adult, Veteran,
- Kidney failure, Liver failure, thrombocytopenia, ALS, SLE, Frailty, unable to understand survery
Study & Design
- Study Type
- INTERVENTIONAL
- Study Design
- PARALLEL
- Arm && Interventions
Group Intervention Description Placebo placebo PLacebo minocycline Minocycline perioperative minocycline for 5 days, starting 2 hours prior to surgery then 100mg BID
- Primary Outcome Measures
Name Time Method Time to Pain Resolution up to 365 days the time until patient answers no pain at surgical site for three consecutive days
- Secondary Outcome Measures
Name Time Method
Trial Locations
- Locations (1)
Palo Alto VA
🇺🇸Palo Alto, California, United States