HES and Acute Kidney Injury in Adult Cardiac Surgery

Completed

• Conditions: Acute Kidney Injury After Adult Cardiac Surgery
• Interventions: Drug: Crystalloid; Drug: HES

• Registration Number: NCT02445820
• Lead Sponsor: University of Liege

Brief Summary

This study retrospectively assess the effect or using balanced hydroxyethyl sctarch (HES) 130/0.4 or a balanced crystalloid solution as a pump prime and for intraoperative fluid therapy on the risk of early acute postoperative kidney injury in adult cardiac surgery patients.

Detailed Description

Not available

Study Timeline

• Study Start: 2014-11
• Study First Submitted: 2015-05-05
• Study First Submitted QC: 2015-05-12
• Study First Posted: 2015-05-15
• Primary Completion: 2015-07
• Study Completion: 2015-07
• Status Verified: 2015-10
• Last Update Submitted: 2015-10-29
• Last Update Posted: 2015-10-30

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 697

Inclusion Criteria

• Age ≥ 18 yo
• Having on pump cardiac surgery at CHU of Liège between April 2013 and June 2014

Exclusion Criteria

• Off pump surgery
• Use of Blood or Albumin in the cardiopulmonary bypass priming solution
• Preoperative dialysis

Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Arm && Interventions

Group	Intervention	Description
Crystalloid	Crystalloid	Balanced Crystalloid used as a pump prime and for intraoperative fluid therapy.
HES	HES	Balanced HES 130/0.4 used as and pump prime and for intraoperative fluid therapy.

Primary Outcome Measures

Name	Time	Method
AKIN SCr	Forty eight hours	Stage of acute kidney injury using the Acute Kidney Injury Network Classification omitting the diuresis criteria.

Secondary Outcome Measures

Name	Time	Method
ICU stay	30 days	Length of stay at the intensive care unit
Hospital stay	30 days	Length of stay at the hospital
30-day mortality	30 days	Death in hospital or within 30 days of surgery
AKIN SCr+UO	Forty eight hours	Stage of acute kidney injury using the Acute Kidney Injury Network Classification including the diuresis criteria.
Postoperative dialysis	30 days	Requirement of postoperative renal replacement therapy
Respiratory complication	30 days	Need for reintubation, non-invasive ventilation or prolonged intensive care unit stay as a consequence of atelectasis, pulmonary edema or pneumonia.