ISRCTN90761040已完成不适用

The protective effect of a nasal corticosteroid (Avamys®) on exercise induced airway obstruction in cold air in children: a randomised double-blind placebo-controlled single-centre trial

Paediatric Research Foundation Enschede, Medical Centre Twente (Netherlands)0 个研究点目标入组 91 人开始时间: 2009年7月3日最近更新: 2015年1月13日

适应症

试验速览

暂无简介。

•1. Both males and females, aged between 12 and 17 years
•2. Clinical history of allergic rhinitis and/or allergic asthma
•3. Ability to perform reproducible lung function tests, i.e. coefficient of the predicted value variation in three of five consecutive measurements less than 5%
•4. Maximal FEV1 greater than 70% of predicted value
•5. Clinically stable period at least three weeks before the study period

•1. Use of intranasal or systemic corticosteroids in the last four weeks prior to the study
•2. Use of antihistamines, cromoglycates, anticholinergics in two weeks prior to the study
•3. Use of long acting bronchodilators 24 hours before testing
•4. Use of short acting bronchodilators eight hours before testing
•5. Use of systemic corticosteroids, antihistamines, cromoglycates, anticholinergics, during the study
•6. Other pulmonary or cardiac disorder
•7. Deviation of the FEV1 of more than 12% from baseline spirometry and the FEV1 before subsequent exercise provocation challenges
•8. Signs of gastro-oesophageal reflux

发起方

Paediatric Research Foundation Enschede, Medical Centre Twente (Netherlands)