Impact of Intensive Exercise Training on Coronary Collateral Circulation in Patients With Stable CAD

Not Applicable

Completed

• Conditions: Stable Coronary Artery Disease
• Interventions: Behavioral: exercise training; Behavioral: Intensive exercise training

• Registration Number: NCT01209637
• Lead Sponsor: University of Leipzig

Brief Summary

Exercise training in patients with coronary artery disease is able to correct several risk factors. Furthermore endothelial function can be improved.

There are some hinds for improved collateral circulation after exercise training, nevertheless there is no study showing significant improvement/ increase in coronary collaterals. This might be due to technique of collateral measurement. Therefore we conduct a study were coronary blod flow before and after 4 weeks of exercise training were measured.

Detailed Description

Not available

Study Timeline

• Study Start: 2010-03
• Study First Submitted: 2010-09-24
• Study First Submitted QC: 2010-09-24
• Study First Posted: 2010-09-27
• Primary Completion: 2012-12
• Study Completion: 2012-12
• Status Verified: 2016-10
• Last Update Submitted: 2016-10-25
• Last Update Posted: 2016-10-26

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 60

Inclusion Criteria

• stable CAD
• min.1 coronary artery stenosis >50%
• patient is symptomatic ( CCS 1-3)or has documented myocardial ischemia during stress test
• angina threshold >75 Watt
• informed consent

Exclusion Criteria

• Age <18 oder >75
• akut coronary syndrome within 2 weeks
• LV-EF < 40 %
• significant valve diseases
• reduced patient compliance
• muscular disorder
• bronchial asthma or COLD stadium III and IV

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: PARALLEL

Arm && Interventions

Group	Intervention	Description
Exercise training	exercise training	exercise training for 4 weeks at 70% of ischemia free individual threshold within a rehabilitation care center
intensive exercise training	Intensive exercise training	intensive exercise training incl. interval training

Primary Outcome Measures

Name	Time	Method
coronary collateral blod flow	4 weeks

Secondary Outcome Measures

Name	Time	Method
plaque composition within the coronary artery	4 weeks	plaque composition measured by virtual histology intravascular ultrasound
MACCE	4 week, 6 months, 12 months	major cardiovascular events (death, myocardial infarction, stroke, TIA, coronary revascularisation, hospitalisation)
atherosclerosis parameter within the laboratory	4 weeks, 3, 6, 12 months	e.g. wie hs-CRP, HDL, LDL, ges. Cholesterin, Triglyceride, Zytokine, Adipokine, Endocannaboide

Trial Locations

Locations (1)

Heart Center Leipzig- University Leipzig; 🇩🇪 Leipzig, Germany