Comparative study of monitoring depth of anaesthesia (bispectral index and Minimum Alveolar Concentration)between two inhalational general anaesthesia agents

Not yet recruiting

• Conditions: Medical and Surgical,

• Registration Number: CTRI/2019/05/019471
• Lead Sponsor: Topiwala national medical college and BYL Nair ch HospitalInstitue

Brief Summary

All the patients who fit inclusion criteria will be randomly selected using computerised table to receive one ofinhalational agent (sevoflurane or desflurane) in combination with air in 50% oxygen formaintenance of anaesthesia. Once the patient achieves stable depth of anaesthesia withtarget BIS value 40-60, patient will be maintained in the same depth by titrating the endtidal concentration of inhalational agent. End tidal concentration and MAC value ofsevoflurane or desflurane will be noted. The study period is predetermined as the 1st 60 minutes after surgical incision as sometime is required to achieve steady state concentration and stable depth of anaesthesiawhich is usually after initial 15 minutes of induction. We will note pulse, blood pressure, SpO2,ETCO2, BIS, inspired concentration of inhalational agent, end tidal concentration of inhalational agent and MAC values every 5 minutesinterval throughout 1 hr of study period.MAC readings will be taken at after initial 15minutes of intubation till 60 minutes after surgical incision. Data will be analysed using appropriate statistical methods.

Detailed Description

Not available

Study Timeline

• Study Start: 2019-03-06
• Last Update Posted: 2019-05-29

Recruitment & Eligibility

• Status: Not Yet Recruiting
• Sex: All
• Target Recruitment: 60

Inclusion Criteria

ASA grade 1 and 2 Elective surgery.

Exclusion Criteria

h/o head injury k/c/o mental retardation k/c/o parenchymal brain disease h/o poisoning drug addiction pregnancy Alzheimer’s disease.

Study & Design

• Study Type: Interventional
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
To compare bispectral index associated MAC values between sevoflurane and	Intraoperative parameters (Hemodynamic parameters, BIS, MAC etc) will be noted after 15 minutes of induction for 60 minutes at every 5 minutes interval
desflurane inhalational general anaesthesia for better understanding of changes in	Intraoperative parameters (Hemodynamic parameters, BIS, MAC etc) will be noted after 15 minutes of induction for 60 minutes at every 5 minutes interval
MAC values.	Intraoperative parameters (Hemodynamic parameters, BIS, MAC etc) will be noted after 15 minutes of induction for 60 minutes at every 5 minutes interval

Secondary Outcome Measures

Name	Time	Method
1.To determine Bispectral index associated Minimum Alveolar Concentration	values of Sevoflurane and Desflurane.

Trial Locations

Locations (1)

TNMC and BYL Nair Ch Hospital; 🇮🇳 Mumbai, MAHARASHTRA, India

TNMC and BYL Nair Ch Hospital

🇮🇳Mumbai, MAHARASHTRA, India

Dr Minal Harde

Principal investigator

02223027137

minalharde@gmail.com